Michael D. Taylor

Research interests

Publications

• Stalled developmental programs at the root of pediatric brain tumors

  Nature Genetics · 2019 · https://doi.org/10.1038/s41588-019-0531-7

• Challenges to curing primary brain tumours

  Nature Reviews Clinical Oncology · 2019 · https://doi.org/10.1038/s41571-019-0177-5

• Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort

  The Lancet Oncology · 2018 · https://doi.org/10.1016/s1470-2045(18)30242-0

• DNA hypermethylation within TERT promoter upregulates TERT expression in cancer

  Journal of Clinical Investigation · 2018 · https://doi.org/10.1172/jci121303

• Intertumoral Heterogeneity within Medulloblastoma Subgroups

  Cancer Cell · 2017 · https://doi.org/10.1016/j.ccell.2017.05.005

• Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas

  Journal of Clinical Oncology · 2017 · https://doi.org/10.1200/jco.2016.71.8726

• Comprehensive Analysis of Hypermutation in Human Cancer

  Cell · 2017 · https://doi.org/10.1016/j.cell.2017.09.048

• Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy

  Nature · 2017 · https://doi.org/10.1038/nature23666

• The whole-genome landscape of medulloblastoma subtypes

  Nature · 2017 · https://doi.org/10.1038/nature22973

• Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity

  Nature · 2017 · https://doi.org/10.1038/nature21356

• Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

  Cancer Cell · 2016 · https://doi.org/10.1016/j.ccell.2016.02.001

• New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

  Cell · 2016 · 10.1016/j.cell.2016.01.015

• Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

  Cancer Cell · 2015 · https://doi.org/10.1016/j.ccell.2015.04.002

• Cytogenetic Prognostication Within Medulloblastoma Subgroups

  Journal of Clinical Oncology · 2014 · https://doi.org/10.1200/jco.2013.50.9539

• Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

  Cancer Cell · 2014 · 10.1016/j.ccr.2014.02.004

• Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

  Nature · 2014 · 10.1038/nature13379

• Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

  Nature · 2014 · https://doi.org/10.1038/nature13108

• Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing

  Nature · 2014 · https://doi.org/10.1038/nature13268

• The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog−driven medulloblastoma

  Nature Medicine · 2014 · https://doi.org/10.1038/nm.3666

• Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

  Nature Genetics · 2013 · 10.1038/ng.2682

• Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis

  The Lancet Oncology · 2013 · https://doi.org/10.1016/s1470-2045(13)70449-2

• Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study

  The Lancet Oncology · 2013 · https://doi.org/10.1016/s1470-2045(13)70110-4

• Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

  Cancer Cell · 2012 · https://doi.org/10.1016/j.ccr.2012.08.024

• Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

  Nature · 2012 · 10.1038/nature11329

• Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations

  Cell · 2012 · 10.1016/j.cell.2011.12.013

• Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

  Acta Neuropathologica · 2012 · 10.1007/s00401-012-0958-8

• Dissecting the genomic complexity underlying medulloblastoma

  Nature · 2012 · 10.1038/nature11284

• Molecular subgroups of medulloblastoma: the current consensus

  Acta Neuropathologica · 2011 · https://doi.org/10.1007/s00401-011-0922-z

• The Genetic Landscape of the Childhood Cancer Medulloblastoma

  Science · 2010 · https://doi.org/10.1126/science.1198056

• Medulloblastoma Comprises Four Distinct Molecular Variants

  Journal of Clinical Oncology · 2010 · https://doi.org/10.1200/jco.2009.27.4324

Current projects

No projects listed.