Alexander Dömlingꝉ

Research interests

Publications

• Covalent inhibitors: a rational approach to drug discovery

  RSC Medicinal Chemistry · 2020 · https://doi.org/10.1039/d0md00154f

• Stapled Peptides Inhibitors: A New Window for Target Drug Discovery

  Computational and Structural Biotechnology Journal · 2019 · https://doi.org/10.1016/j.csbj.2019.01.012

• Metabolic signature of obesity-associated insulin resistance and type 2 diabetes

  Journal of Translational Medicine · 2019 · https://doi.org/10.1186/s12967-019-2096-8

• Tetrazoles via Multicomponent Reactions

  Chemical Reviews · 2019 · https://doi.org/10.1021/acs.chemrev.8b00564

• Structural Biology of the Immune Checkpoint Receptor PD-1 and Its Ligands PD-L1/PD-L2

  Structure · 2017 · https://doi.org/10.1016/j.str.2017.06.011

• Bioactive Macrocyclic Inhibitors of the PD‐1/PD‐L1 Immune Checkpoint

  Angewandte Chemie International Edition · 2017 · https://doi.org/10.1002/anie.201707707

• Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells

  Oncotarget · 2017 · https://doi.org/10.18632/oncotarget.20050

• Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1

  Journal of Medicinal Chemistry · 2017 · https://doi.org/10.1021/acs.jmedchem.7b00293

• Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1)

  Oncotarget · 2016 · https://doi.org/10.18632/oncotarget.8730

• Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1

  Structure · 2015 · https://doi.org/10.1016/j.str.2015.09.010

• Multicomponent Reactions, Union of MCRs and Beyond

  The Chemical Record · 2015 · https://doi.org/10.1002/tcr.201500201

• Chemistry and Biology Of Multicomponent Reactions

  Chemical Reviews · 2012 · https://doi.org/10.1021/cr100233r

• Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery

  Cell Cycle · 2010 · https://doi.org/10.4161/cc.9.6.10956

• The Gewald multicomponent reaction

  Molecular Diversity · 2010 · https://doi.org/10.1007/s11030-010-9229-6

• Recent Developments in Isocyanide Based Multicomponent Reactions in Applied Chemistry

  Chemical Reviews · 2005 · https://doi.org/10.1021/cr0505728

• The Chemistry of Isocyanides, their MultiComponent Reactions and their Libraries

  Molecules · 2003 · https://doi.org/10.3390/80100053

• Recent advances in isocyanide-based multicomponent chemistry

  Current Opinion in Chemical Biology · 2002 · https://doi.org/10.1016/s1367-5931(02)00328-9

• Since 1995 the new chemistry of multicomponent reactions and their libraries, including their heterocyclic chemistry

  Journal of Heterocyclic Chemistry · 2000 · https://doi.org/10.1002/jhet.5570370322

• The discovery of new isocyanide-based multi-component reactions

  Current Opinion in Chemical Biology · 2000 · https://doi.org/10.1016/s1367-5931(00)00095-8

• Multicomponent Reactions with Isocyanides

  Angewandte Chemie International Edition · 2000 · https://doi.org/10.1002/1521-3773(20000915)39:18<3168::aid-anie3168>3.0.co;2-u

• Multikomponentenreaktionen mit Isocyaniden

  Angewandte Chemie · 2000 · https://doi.org/10.1002/1521-3757(20000915)112:18<3300::aid-ange3300>3.0.co;2-z

• Multicomponent reactions in organic chemistry

  Endeavour · 1994 · https://doi.org/10.1016/s0160-9327(05)80086-9

Current projects

No projects listed.