Harshil Patel

Research interests

Publications

• Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation

  Nature Cell Biology · 2022 · 10.1038/s41556-022-00910-2

• A systematic benchmark of Nanopore long read RNA sequencing for transcript level analysis in human cell lines

  bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 10.1101/2021.04.21.440736

• Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA -deficient cells to PARP inhibitors

  Science · 2021 · 10.1126/science.abb4542

• The nf-core framework for community-curated bioinformatics pipelines

  Nature Biotechnology · 2020 · https://doi.org/10.1038/s41587-020-0439-x

• Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection

  Nature Immunology · 2020 · 10.1038/s41590-019-0568-x

• Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

  Molecular Cell · 2020 · 10.1016/j.molcel.2020.12.006

• A Role for Chromatin Remodeling in Cohesin Loading onto Chromosomes

  Molecular Cell · 2019 · 10.1016/j.molcel.2019.02.027

• ATAD3 gene cluster deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism

  Brain · 2017 · 10.1093/brain/awx094

• The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity

  Science · 2016 · 10.1126/science.aaf1644

• Chromatin Controls DNA Replication Origin Selection, Lagging-Strand Synthesis, and Replication Fork Rates

  Molecular Cell · 2016 · 10.1016/j.molcel.2016.11.016

• SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair

  Oncogene · 2015 · 10.1038/onc.2015.24

• The Scc2–Scc4 complex acts in sister chromatid cohesion and transcriptional regulation by maintaining nucleosome-free regions

  Nature Genetics · 2014 · 10.1038/ng.3080

Current projects

No projects listed.