Frank J. M. van Kuppeveld

Research interests

Publications

• A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies

  Nature Communications · 2021 · https://doi.org/10.1038/s41467-021-21968-w

• A human monoclonal antibody blocking SARS-CoV-2 infection

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-020-16256-y

• Small molecule ISRIB suppresses the integrated stress response within a defined window of activation

  Proceedings of the National Academy of Sciences · 2019 · https://doi.org/10.1073/pnas.1815767116

• Human coronaviruses OC43 and HKU1 bind to 9- O -acetylated sialic acids via a conserved receptor-binding site in spike protein domain A

  Proceedings of the National Academy of Sciences · 2019 · https://doi.org/10.1073/pnas.1809667116

• Broad receptor engagement of an emerging global coronavirus may potentiate its diverse cross-species transmissibility

  Proceedings of the National Academy of Sciences · 2018 · https://doi.org/10.1073/pnas.1802879115

• The life cycle of non-polio enteroviruses and how to target it

  Nature Reviews Microbiology · 2018 · https://doi.org/10.1038/s41579-018-0005-4

• PLA2G16 represents a switch between entry and clearance of Picornaviridae

  Nature · 2017 · https://doi.org/10.1038/nature21032

• Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication

  PLoS Pathogens · 2017 · https://doi.org/10.1371/journal.ppat.1006195

• Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein

  Proceedings of the National Academy of Sciences · 2017 · https://doi.org/10.1073/pnas.1712592114

• Cellular entry of the porcine epidemic diarrhea virus

  Virus Research · 2016 · https://doi.org/10.1016/j.virusres.2016.05.031

• Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses

  PLoS Pathogens · 2016 · https://doi.org/10.1371/journal.ppat.1005982

• Sensing of latent EBV infection through exosomal transfer of 5′pppRNA

  Proceedings of the National Academy of Sciences · 2016 · https://doi.org/10.1073/pnas.1518130113

• Stress Granules Regulate Double-Stranded RNA-Dependent Protein Kinase Activation through a Complex Containing G3BP1 and Caprin1

  mBio · 2015 · 10.1128/mbio.02486-14

• Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein

  Cell Reports · 2015 · https://doi.org/10.1016/j.celrep.2014.12.054

• Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner

  PLoS Pathogens · 2014 · https://doi.org/10.1371/journal.ppat.1004502

• Enterovirus 2A pro Targets MDA5 and MAVS in Infected Cells

  Journal of Virology · 2014 · https://doi.org/10.1128/jvi.02712-13

• Rhinovirus Uses a Phosphatidylinositol 4-Phosphate/Cholesterol Counter-Current for the Formation of Replication Compartments at the ER-Golgi Interface

  Cell Host & Microbe · 2014 · https://doi.org/10.1016/j.chom.2014.10.003

• The Receptor Binding Domain of the New Middle East Respiratory Syndrome Coronavirus Maps to a 231-Residue Region in the Spike Protein That Efficiently Elicits Neutralizing Antibodies

  Journal of Virology · 2013 · https://doi.org/10.1128/jvi.01277-13

• MDA5 Detects the Double-Stranded RNA Replicative Form in Picornavirus-Infected Cells

  Cell Reports · 2012 · https://doi.org/10.1016/j.celrep.2012.10.005

• The Transformation of Enterovirus Replication Structures: a Three-Dimensional Study of Single- and Double-Membrane Compartments

  mBio · 2011 · https://doi.org/10.1128/mbio.00166-11

• Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication

  Cell · 2010 · https://doi.org/10.1016/j.cell.2010.03.050

• GBF1, a Guanine Nucleotide Exchange Factor for Arf, Is Crucial for Coxsackievirus B3 RNA Replication

  Journal of Virology · 2009 · https://doi.org/10.1128/jvi.01244-09

• Antiviral Activity of the Zinc Ionophores Pyrithione and Hinokitiol against Picornavirus Infections

  Journal of Virology · 2008 · https://doi.org/10.1128/jvi.01543-08

• Mouse Hepatitis Coronavirus RNA Replication Depends on GBF1-Mediated ARF1 Activation

  PLoS Pathogens · 2008 · https://doi.org/10.1371/journal.ppat.1000088

• Coxsackievirus protein 2B modifies endoplasmic reticulum membrane and plasma membrane permeability and facilitates virus release

  The EMBO Journal · 1997 · https://doi.org/10.1093/emboj/16.12.3519

Current projects

No projects listed.