Elaine Holmes

Research interests

Publications

• The gut microbiota influences skeletal muscle mass and function in mice

  Science Translational Medicine · 2019 · https://doi.org/10.1126/scitranslmed.aan5662

• Serum metabolic signatures of coronary and carotid atherosclerosis and subsequent cardiovascular disease

  European Heart Journal · 2019 · https://doi.org/10.1093/eurheartj/ehz235

• Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

  Nature Medicine · 2018 · 10.1038/s41591-018-0061-3

• A Prospective Metagenomic and Metabolomic Analysis of the Impact of Exercise and/or Whey Protein Supplementation on the Gut Microbiome of Sedentary Adults

  mSystems · 2018 · https://doi.org/10.1128/msystems.00044-18

• The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level

  Gut · 2017 · https://doi.org/10.1136/gutjnl-2016-313627

• The vaginal microbiome during pregnancy and the postpartum period in a European population

  Scientific Reports · 2015 · 10.1038/srep08988

• Precision High-Throughput Proton NMR Spectroscopy of Human Urine, Serum, and Plasma for Large-Scale Metabolic Phenotyping

  Analytical Chemistry · 2014 · 10.1021/ac5025039

• Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor

  Science · 2013 · https://doi.org/10.1126/science.1229000

• Global metabolic profiling of animal and human tissues via UPLC-MS

  Nature Protocols · 2012 · https://doi.org/10.1038/nprot.2012.135

• Host-Gut Microbiota Metabolic Interactions

  Science · 2012 · https://doi.org/10.1126/science.1223813

• Understanding the role of gut microbiome–host metabolic signal disruption in health and disease

  Trends in Microbiology · 2011 · 10.1016/j.tim.2011.05.006

• Metabolic surgery profoundly influences gut microbial–host metabolic cross-talk

  Gut · 2011 · https://doi.org/10.1136/gut.2010.234708

• Global metabolic profiling procedures for urine using UPLC–MS

  Nature Protocols · 2010 · 10.1038/nprot.2010.50

• Systemic gut microbial modulation of bile acid metabolism in host tissue compartments

  Proceedings of the National Academy of Sciences · 2010 · 10.1073/pnas.1006734107

• Human metabolic phenotype diversity and its association with diet and blood pressure

  Nature · 2008 · 10.1038/nature06882

• Symbiotic gut microbes modulate human metabolic phenotypes

  Proceedings of the National Academy of Sciences · 2008 · https://doi.org/10.1073/pnas.0712038105

• Metabolic Phenotyping in Health and Disease

  Cell · 2008 · 10.1016/j.cell.2008.08.026

• Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts

  Nature Protocols · 2007 · https://doi.org/10.1038/nprot.2007.376

• Rapid and Noninvasive Metabonomic Characterization of Inflammatory Bowel Disease

  Journal of Proteome Research · 2007 · 10.1021/pr060470d

• Chemometrics in Metabonomics

  Journal of Proteome Research · 2006 · 10.1021/pr060594q

• Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice

  Proceedings of the National Academy of Sciences · 2006 · 10.1073/pnas.0601056103

• OPLS discriminant analysis: combining the strengths of PLS‐DA and SIMCA classification

  Journal of Chemometrics · 2006 · 10.1002/cem.1006

• Statistical Total Correlation Spectroscopy: An Exploratory Approach for Latent Biomarker Identification from Metabolic 1 H NMR Data Sets

  Analytical Chemistry · 2005 · 10.1021/ac048630x

• Gut microorganisms, mammalian metabolism and personalized health care

  Nature Reviews Microbiology · 2005 · 10.1038/nrmicro1152

• A Metabonomic Strategy for the Detection of the Metabolic Effects of Chamomile (Matricaria recutita L.) Ingestion

  Journal of Agricultural and Food Chemistry · 2004 · https://doi.org/10.1021/jf0403282

• Evaluation of the Orthogonal Projection on Latent Structure Model Limitations Caused by Chemical Shift Variability and Improved Visualization of Biomarker Changes in 1 H NMR Spectroscopic Metabonomic Studies

  Analytical Chemistry · 2004 · 10.1021/ac048803i

• Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics

  Nature Medicine · 2002 · 10.1038/nm1202-802

• Metabonomics: a platform for studying drug toxicity and gene function

  Nature Reviews Drug Discovery · 2002 · https://doi.org/10.1038/nrd728

• 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data

  Xenobiotica · 1999 · https://doi.org/10.1080/004982599238047

Current projects

No projects listed.