Vassilis G. Gorgoulis

Research interests

Publications

• Guidelines for minimal information on cellular senescence experimentation in vivo

  Cell · 2024 · 10.1016/j.cell.2024.05.059

• FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2

  Nature · 2022 · 10.1038/s41586-022-05594-0

• Mitochondrial Homeostasis and Cellular Senescence

  Cells · 2019 · 10.3390/cells8070686

• Cellular Senescence: Defining a Path Forward

  Cell · 2019 · https://doi.org/10.1016/j.cell.2019.10.005

• A Deep Learning Framework for Predicting Response to Therapy in Cancer

  Cell Reports · 2019 · https://doi.org/10.1016/j.celrep.2019.11.017

• Apidima Cave fossils provide earliest evidence of Homo sapiens in Eurasia

  Nature · 2019 · 10.1038/s41586-019-1376-z

• Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246

  Nature Communications · 2018 · 10.1038/s41467-018-03224-w

• Ageing, Cellular Senescence and Neurodegenerative Disease

  International Journal of Molecular Sciences · 2018 · 10.3390/ijms19102937

• Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

  Nature Cell Biology · 2016 · 10.1038/ncb3378

• Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks

  Molecular Cell · 2016 · 10.1016/j.molcel.2016.10.038

• Robust, universal biomarker assay to detect senescent cells in biological specimens

  Aging Cell · 2016 · 10.1111/acel.12545

• Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation

  Cell Death and Differentiation · 2014 · 10.1038/cdd.2014.16

• Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer

  Cancer Cell · 2013 · 10.1016/j.ccr.2013.03.022

• Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues

  Aging · 2012 · 10.18632/aging.100527

• Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer

  Nature Cell Biology · 2011 · 10.1038/ncb2170

• Genomic instability — an evolving hallmark of cancer

  Nature Reviews Molecular Cell Biology · 2010 · https://doi.org/10.1038/nrm2858

• Oncogene-induced senescence: the bright and dark side of the response

  Current Opinion in Cell Biology · 2010 · 10.1016/j.ceb.2010.07.013

• Hypomethylation of retrotransposable elements correlates with genomic instability in non‐small cell lung cancer

  International Journal of Cancer · 2008 · 10.1002/ijc.23849

• An Oncogene-Induced DNA Damage Model for Cancer Development

  Science · 2008 · https://doi.org/10.1126/science.1140735

• Advances in the biology of oral cancer

  Oral Oncology · 2007 · 10.1016/j.oraloncology.2006.11.010

• Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study

  Oncogene · 2007 · https://doi.org/10.1038/sj.onc.1210989

• Deregulated Overexpression of hCdt1 and hCdc6 Promotes Malignant Behavior

  Cancer Research · 2007 · 10.1158/0008-5472.can-07-2837

• Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

  Nature · 2006 · https://doi.org/10.1038/nature05268

• Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

  Nature · 2005 · https://doi.org/10.1038/nature03485

• Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

  Nature · 2004 · 10.1038/nature03114

• “High Risk” HPV Types Are Frequently Detected in Potentially Malignant and Malignant Oral Lesions, But Not in Normal Oral Mucosa

  Modern Pathology · 2000 · 10.1038/modpathol.3880113

Current projects

No projects listed.