Dario R. Alessi

Research interests

Publications

• LRRK2 activation in idiopathic Parkinson’s disease

  Science Translational Medicine · 2018 · https://doi.org/10.1126/scitranslmed.aar5429

• Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

  eLife · 2016 · https://doi.org/10.7554/elife.12813

• Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

  Biochemical Journal · 2014 · https://doi.org/10.1042/bj20140334

• PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

  Open Biology · 2012 · https://doi.org/10.1098/rsob.120080

• The nuts and bolts of AGC protein kinases

  Nature Reviews Molecular Cell Biology · 2009 · https://doi.org/10.1038/nrm2822

• New Users of Metformin Are at Low Risk of Incident Cancer

  Diabetes Care · 2009 · https://doi.org/10.2337/dc08-2175

• mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

  Biochemical Journal · 2008 · https://doi.org/10.1042/bj20081668

• The selectivity of protein kinase inhibitors: a further update

  Biochemical Journal · 2007 · https://doi.org/10.1042/bj20070797

• LKB1-Dependent Signaling Pathways

  Annual Review of Biochemistry · 2006 · https://doi.org/10.1146/annurev.biochem.75.103004.142702

• Metformin and reduced risk of cancer in diabetic patients

  BMJ · 2005 · https://doi.org/10.1136/bmj.38415.708634.f7

• LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1

  The EMBO Journal · 2004 · https://doi.org/10.1038/sj.emboj.7600110

• PDK1, the master regulator of AGC kinase signal transduction

  Seminars in Cell and Developmental Biology · 2004 · https://doi.org/10.1016/j.semcdb.2003.12.022

• Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

  Journal of Biology · 2003 · https://doi.org/10.1186/1475-4924-2-28

• PKB/Akt

  Journal of Cell Science · 2001 · https://doi.org/10.1242/jcs.114.16.2903

• The PI3K–PDK1 connection: more than just a road to PKB

  Biochemical Journal · 2000 · https://doi.org/10.1042/bj3460561

• Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation

  Biochemical Journal · 1999 · https://doi.org/10.1042/bj3440427

• Protein Kinase C Isotypes Controlled by Phosphoinositide 3-Kinase Through the Protein Kinase PDK1

  Science · 1998 · https://doi.org/10.1126/science.281.5385.2042

• Mechanism of activation and function of protein kinase B

  Current Opinion in Genetics & Development · 1998 · https://doi.org/10.1016/s0959-437x(98)80062-2

• Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

  Current Biology · 1997 · https://doi.org/10.1016/s0960-9822(06)00122-9

• Role of Translocation in the Activation and Function of Protein Kinase B

  Journal of Biological Chemistry · 1997 · https://doi.org/10.1074/jbc.272.50.31515

• 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

  Current Biology · 1997 · https://doi.org/10.1016/s0960-9822(06)00336-8

• Mechanism of activation of protein kinase B by insulin and IGF‐1.

  The EMBO Journal · 1996 · https://doi.org/10.1002/j.1460-2075.1996.tb01045.x

• Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase

  FEBS Letters · 1996 · https://doi.org/10.1016/s0014-5793(96)01370-1

• PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

  Journal of Biological Chemistry · 1995 · https://doi.org/10.1074/jbc.270.46.27489

• Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

  Nature · 1995 · https://doi.org/10.1038/378785a0

Current projects

No projects listed.