Joshua D. Rabinowitz

Research interests

Publications

• Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate

  Nature · 2020 · https://doi.org/10.1038/s41586-020-2101-7

• Glucose feeds the TCA cycle via circulating lactate

  Nature · 2017 · https://doi.org/10.1038/nature24057

• Mitochondria and Cancer

  Molecular Cell · 2016 · https://doi.org/10.1016/j.molcel.2016.02.011

• One-Carbon Metabolism in Health and Disease

  Cell Metabolism · 2016 · https://doi.org/10.1016/j.cmet.2016.08.009

• Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production

  Cell Metabolism · 2016 · https://doi.org/10.1016/j.cmet.2016.04.022

• A roadmap for interpreting 13C metabolite labeling patterns from cells

  Current Opinion in Biotechnology · 2015 · https://doi.org/10.1016/j.copbio.2015.02.003

• Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

  Nature · 2013 · 10.1038/nature12138

• Evidence for an alternative glycolytic pathway in rapidly proliferating cells

  Europe PMC (PubMed Central) · 2010 · https://doi.org/10.1126/science.1188015

• The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

  Cancer Cell · 2010 · https://doi.org/10.1016/j.ccr.2010.01.020

• Autophagy and Metabolism

  Science · 2010 · https://doi.org/10.1126/science.1193497

• Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli

  Nature Chemical Biology · 2009 · https://doi.org/10.1038/nchembio.186

• Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

  Nature · 2009 · https://doi.org/10.1038/nature08617

Current projects

No projects listed.