Stefan Fröhling

Research interests

Publications

• Accurate and efficient detection of gene fusions from RNA sequencing data

  Genome Research · 2021 · 10.1101/gr.257246.119

• Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers

  Cancer Discovery · 2021 · 10.1158/2159-8290.cd-21-0126

• Small-molecule-induced polymerization triggers degradation of BCL6

  Nature · 2020 · 10.1038/s41586-020-2925-1

• Caring for patients with cancer in the COVID-19 era

  Nature Medicine · 2020 · 10.1038/s41591-020-0874-8

• The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

  Nature · 2020 · 10.1038/s41586-020-2374-x

• Implementing tumor mutational burden (TMB) analysis in routine diagnostics—a primer for molecular pathologists and clinicians

  Translational Lung Cancer Research · 2018 · 10.21037/tlcr.2018.08.14

• Integrative genomic and transcriptomic analysis of leiomyosarcoma

  Nature Communications · 2018 · 10.1038/s41467-017-02602-0

• NRG1 Fusions in KRAS Wild-Type Pancreatic Cancer

  Cancer Discovery · 2018 · 10.1158/2159-8290.cd-18-0036

• BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

  Nature · 2017 · 10.1038/nature24294

• Exercise Training Improves Exercise Capacity and Diastolic Function in Patients With Heart Failure With Preserved Ejection Fraction

  Journal of the American College of Cardiology · 2011 · 10.1016/j.jacc.2011.06.054

• TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome

  Blood · 2011 · https://doi.org/10.1182/blood-2011-08-375758

• AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias

  Cell · 2011 · 10.1016/j.cell.2011.07.032

• Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

  Nature Medicine · 2010 · 10.1038/nm.2187

• Synthetic Lethal Interaction between Oncogenic KRAS Dependency and STK33 Suppression in Human Cancer Cells

  Cell · 2009 · 10.1016/j.cell.2009.03.017

• Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

  Nature · 2009 · https://doi.org/10.1038/nature08460

• Activating mutations in ALK provide a therapeutic target in neuroblastoma

  Nature · 2008 · https://doi.org/10.1038/nature07397

• Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid Leukemia

  New England Journal of Medicine · 2008 · https://doi.org/10.1056/nejmoa074306

• Cytogenetics and age are major determinants of outcome in intensively treated acute myeloid leukemia patients older than 60 years: results from AMLSG trial AML HD98-B

  Blood · 2006 · 10.1182/blood-2006-04-014324

• Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations

  Blood · 2005 · 10.1182/blood-2005-05-2164

• Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

  Cancer Cell · 2005 · https://doi.org/10.1016/j.ccr.2005.03.023

• Genetics of Myeloid Malignancies: Pathogenetic and Clinical Implications

  Journal of Clinical Oncology · 2005 · 10.1200/jco.2005.05.010

• CEBPA Mutations in Younger Adults With Acute Myeloid Leukemia and Normal Cytogenetics: Prognostic Relevance and Analysis of Cooperating Mutations

  Journal of Clinical Oncology · 2004 · 10.1200/jco.2004.06.060

• Use of Gene-Expression Profiling to Identify Prognostic Subclasses in Adult Acute Myeloid Leukemia

  New England Journal of Medicine · 2004 · 10.1056/nejmoa031046

• Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm

  Blood · 2002 · 10.1182/blood-2002-05-1440

• Prognostic Significance of Partial Tandem Duplications of the MLL Gene in Adult Patients 16 to 60 Years Old With Acute Myeloid Leukemia and Normal Cytogenetics: A Study of the Acute Myeloid Leukemia Study Group Ulm

  Journal of Clinical Oncology · 2002 · 10.1200/jco.2002.09.088

Current projects

No projects listed.