Marcel Kool

Research interests

Publications

• Sarcoma classification by DNA methylation profiling

  Nature Communications · 2021 · https://doi.org/10.1038/s41467-020-20603-4

• The landscape of genomic alterations across childhood cancers

  Nature · 2018 · https://doi.org/10.1038/nature25480

• The whole-genome landscape of medulloblastoma subtypes

  Nature · 2017 · https://doi.org/10.1038/nature22973

• Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis

  Journal of Clinical Oncology · 2016 · https://doi.org/10.1200/jco.2015.65.7825

• Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

  Cancer Cell · 2016 · https://doi.org/10.1016/j.ccell.2016.02.001

• Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

  The Lancet Oncology · 2016 · https://doi.org/10.1016/s1470-2045(15)00581-1

• Mutations in the SIX1/2 Pathway and the DROSHA/DGCR8 miRNA Microprocessor Complex Underlie High-Risk Blastemal Type Wilms Tumors

  Cancer Cell · 2015 · https://doi.org/10.1016/j.ccell.2015.01.002

• Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

  Cancer Cell · 2015 · https://doi.org/10.1016/j.ccell.2015.04.002

• The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog−driven medulloblastoma

  Nature Medicine · 2014 · https://doi.org/10.1038/nm.3666

• Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

  Cancer Cell · 2014 · https://doi.org/10.1016/j.ccr.2014.02.004

• Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

  Nature · 2014 · https://doi.org/10.1038/nature13379

• Cytogenetic Prognostication Within Medulloblastoma Subgroups

  Journal of Clinical Oncology · 2014 · https://doi.org/10.1200/jco.2013.50.9539

• Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis

  The Lancet Oncology · 2013 · https://doi.org/10.1016/s1470-2045(13)70449-2

• Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas

  Cancer Cell · 2013 · 10.1016/j.ccr.2013.10.006

• Signatures of mutational processes in human cancer

  Nature · 2013 · https://doi.org/10.1038/nature12477

• Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study

  The Lancet Oncology · 2013 · https://doi.org/10.1016/s1470-2045(13)70110-4

• Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

  Nature Genetics · 2013 · 10.1038/ng.2682

• Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas

  Acta Neuropathologica · 2013 · https://doi.org/10.1007/s00401-013-1095-8

• Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations

  Acta Neuropathologica · 2012 · https://doi.org/10.1007/s00401-012-1031-3

• Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

  Acta Neuropathologica · 2012 · 10.1007/s00401-012-0958-8

• Dissecting the genomic complexity underlying medulloblastoma

  Nature · 2012 · 10.1038/nature11284

• Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations

  Cell · 2012 · 10.1016/j.cell.2011.12.013

• Subgroup-specific structural variation across 1,000 medulloblastoma genomes

  Nature · 2012 · 10.1038/nature11327

• Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

  Cancer Cell · 2012 · https://doi.org/10.1016/j.ccr.2012.08.024

• Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

  Nature · 2012 · https://doi.org/10.1038/nature10833

• K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

  Acta Neuropathologica · 2012 · 10.1007/s00401-012-0998-0

• Molecular subgroups of medulloblastoma: the current consensus

  Acta Neuropathologica · 2011 · https://doi.org/10.1007/s00401-011-0922-z

• A Family of Drug Transporters: the Multidrug Resistance-Associated Proteins

  JNCI Journal of the National Cancer Institute · 2000 · https://doi.org/10.1093/jnci/92.16.1295

Current projects

No projects listed.