Stefan M. Pfister

Research interests

Publications

• The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

  Neuro-Oncology · 2021 · https://doi.org/10.1093/neuonc/noab106

• The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets

  Cancer Discovery · 2021 · https://doi.org/10.1158/2159-8290.cd-21-0094

• CDKN2A/B homozygous deletion is associated with early recurrence in meningiomas

  Acta Neuropathologica · 2020 · https://doi.org/10.1007/s00401-020-02188-w

• Larotrectinib in patients with TRK fusion-positive solid tumours: a pooled analysis of three phase 1/2 clinical trials

  The Lancet Oncology · 2020 · https://doi.org/10.1016/s1470-2045(19)30856-3

• Challenges to curing primary brain tumours

  Nature Reviews Clinical Oncology · 2019 · https://doi.org/10.1038/s41571-019-0177-5

• The landscape of genomic alterations across childhood cancers

  Nature · 2018 · https://doi.org/10.1038/nature25480

• Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma

  Cancer Cell · 2017 · https://doi.org/10.1016/j.ccell.2017.08.017

• The whole-genome landscape of medulloblastoma subtypes

  Nature · 2017 · 10.1038/nature22973

• DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis

  The Lancet Oncology · 2017 · 10.1016/s1470-2045(17)30155-9

• Global epigenetic profiling identifies methylation subgroups associated with recurrence-free survival in meningioma

  Acta Neuropathologica · 2017 · https://doi.org/10.1007/s00401-017-1678-x

• Childhood cancer predisposition syndromes—A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology

  American Journal of Medical Genetics Part A · 2017 · https://doi.org/10.1002/ajmg.a.38142

• Cancer Screening Recommendations for Individuals with Li-Fraumeni Syndrome

  Clinical Cancer Research · 2017 · https://doi.org/10.1158/1078-0432.ccr-17-0408

• Next-generation personalised medicine for high-risk paediatric cancer patients – The INFORM pilot study

  European Journal of Cancer · 2016 · https://doi.org/10.1016/j.ejca.2016.06.009

• Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

  Cancer Cell · 2016 · https://doi.org/10.1016/j.ccell.2016.02.001

• Mutations in the SIX1/2 Pathway and the DROSHA/DGCR8 miRNA Microprocessor Complex Underlie High-Risk Blastemal Type Wilms Tumors

  Cancer Cell · 2015 · https://doi.org/10.1016/j.ccell.2015.01.002

• A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing

  Nature Communications · 2015 · https://doi.org/10.1038/ncomms10001

• Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

  Cancer Cell · 2015 · 10.1016/j.ccell.2015.04.002

• Glioma

  Nature Reviews Disease Primers · 2015 · 10.1038/nrdp.2015.17

• Cytogenetic Prognostication Within Medulloblastoma Subgroups

  Journal of Clinical Oncology · 2014 · https://doi.org/10.1200/jco.2013.50.9539

• The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog−driven medulloblastoma

  Nature Medicine · 2014 · https://doi.org/10.1038/nm.3666

• Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

  Cancer Cell · 2014 · 10.1016/j.ccr.2014.02.004

• Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

  Nature · 2014 · 10.1038/nature13379

• Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis

  The Lancet Oncology · 2013 · https://doi.org/10.1016/s1470-2045(13)70449-2

• Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas

  Cancer Cell · 2013 · 10.1016/j.ccr.2013.10.006

• Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas

  Acta Neuropathologica · 2013 · https://doi.org/10.1007/s00401-013-1095-8

• Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study

  The Lancet Oncology · 2013 · https://doi.org/10.1016/s1470-2045(13)70110-4

• Signatures of mutational processes in human cancer

  Nature · 2013 · https://doi.org/10.1038/nature12477

• Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

  Nature · 2012 · https://doi.org/10.1038/nature10833

• Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations

  Acta Neuropathologica · 2012 · https://doi.org/10.1007/s00401-012-1031-3

• Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

  Cancer Cell · 2012 · https://doi.org/10.1016/j.ccr.2012.08.024

• Dissecting the genomic complexity underlying medulloblastoma

  Nature · 2012 · 10.1038/nature11284

• K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

  Acta Neuropathologica · 2012 · 10.1007/s00401-012-0998-0

• Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

  Acta Neuropathologica · 2012 · 10.1007/s00401-012-0958-8

• Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

  Nature · 2012 · 10.1038/nature11329

• Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations

  Cell · 2012 · 10.1016/j.cell.2011.12.013

• Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma

  Acta Neuropathologica · 2011 · 10.1007/s00401-011-0802-6

• Molecular subgroups of medulloblastoma: the current consensus

  Acta Neuropathologica · 2011 · https://doi.org/10.1007/s00401-011-0922-z

• Medulloblastoma Comprises Four Distinct Molecular Variants

  Journal of Clinical Oncology · 2010 · 10.1200/jco.2009.27.4324

• DNA methylation pattern changes upon long‐term culture and aging of human mesenchymal stromal cells

  Aging Cell · 2009 · https://doi.org/10.1111/j.1474-9726.2009.00535.x

• Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process

  PLoS ONE · 2008 · 10.1371/journal.pone.0002213

Current projects

No projects listed.