Charles D. Imbusch

Research interests

Publications

• Spatially Resolved Multi-Omics Single-Cell Analyses Inform Mechanisms of Immune Dysfunction in Pancreatic Cancer

  Gastroenterology · 2023 · 10.1053/j.gastro.2023.05.036

• Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells

  Immunity · 2021 · 10.1016/j.immuni.2021.03.007

• Aggressive PDACs Show Hypomethylation of Repetitive Elements and the Execution of an Intrinsic IFN Program Linked to a Ductal Cell of Origin

  Cancer Discovery · 2020 · 10.1158/2159-8290.cd-20-1202

• Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF

  Immunity · 2020 · 10.1016/j.immuni.2019.12.002

• Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues

  Nature Immunology · 2017 · 10.1038/ni.3799

• DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats

  Nature Genetics · 2017 · 10.1038/ng.3889

• The whole-genome landscape of medulloblastoma subtypes

  Nature · 2017 · https://doi.org/10.1038/nature22973

• Epigenomic Profiling of Human CD4+ T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development

  Immunity · 2016 · 10.1016/j.immuni.2016.10.022

• DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia

  Nature Genetics · 2016 · 10.1038/ng.3488

• Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

  Nature · 2014 · https://doi.org/10.1038/nature13379

• Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2682

Current projects

No projects listed.