B. Matija Peterlin

Research interests

Publications

• An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression

  PLoS Pathogens · 2015 · https://doi.org/10.1371/journal.ppat.1005063

• The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes

  Genes & Development · 2011 · https://doi.org/10.1101/gad.16962311

• Suberoylanilide Hydroxamic Acid Reactivates HIV from Latently Infected Cells

  Journal of Biological Chemistry · 2009 · https://doi.org/10.1074/jbc.m807898200

• HIV Nef is Secreted in Exosomes and Triggers Apoptosis in Bystander CD4+ T Cells

  Traffic · 2009 · https://doi.org/10.1111/j.1600-0854.2009.01006.x

• Transcriptional Interference Antagonizes Proviral Gene Expression to Promote HIV Latency

  Cell Host & Microbe · 2008 · https://doi.org/10.1016/j.chom.2008.05.016

• HMBA Releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and Activates HIV Transcription

  PLoS Pathogens · 2007 · https://doi.org/10.1371/journal.ppat.0030146

• Controlling the Elongation Phase of Transcription with P-TEFb

  Molecular Cell · 2006 · https://doi.org/10.1016/j.molcel.2006.06.014

• Human APOBEC3F Is Another Host Factor That Blocks Human Immunodeficiency Virus Type 1 Replication

  Journal of Virology · 2004 · https://doi.org/10.1128/jvi.78.11.6073-6076.2004

• Dynamics of Human Immunodeficiency Virus Transcription: P-TEFb Phosphorylates RD and Dissociates Negative Effectors from the Transactivation Response Element

  Molecular and Cellular Biology · 2003 · https://doi.org/10.1128/mcb.24.2.787-795.2004

• Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy

  Nature Medicine · 2002 · https://doi.org/10.1038/nm0702-673

• NF-κB Binds P-TEFb to Stimulate Transcriptional Elongation by RNA Polymerase II

  Molecular Cell · 2001 · https://doi.org/10.1016/s1097-2765(01)00314-8

• Structure–function relationships in HIV‐1 Nef

  EMBO Reports · 2001 · https://doi.org/10.1093/embo-reports/kve141

• Tat Competes with CIITA for the Binding to P-TEFb and Blocks the Expression of MHC Class II Genes in HIV Infection

  Immunity · 2000 · https://doi.org/10.1016/s1074-7613(00)80159-4

• Flavopiridol Inhibits P-TEFb and Blocks HIV-1 Replication

  Journal of Biological Chemistry · 2000 · https://doi.org/10.1074/jbc.c000446200

• Activation of Vav by Nef Induces Cytoskeletal Rearrangements and Downstream Effector Functions

  Molecular Cell · 1999 · https://doi.org/10.1016/s1097-2765(01)80005-8

• Interactions between HIV1 Nef and Vacuolar ATPase Facilitate the Internalization of CD4

  Immunity · 1998 · https://doi.org/10.1016/s1074-7613(00)80569-5

• Human immunodeficiency virus type 1 Nef associateswith a cellular serine kinase in T lymphocytes.

  Proceedings of the National Academy of Sciences · 1994 · https://doi.org/10.1073/pnas.91.4.1539

• HIV-1 nef leads to inhibition or activation of T cells depending on its intracellular localization

  Immunity · 1994 · https://doi.org/10.1016/1074-7613(94)90068-x

• CONTROL OF RNA INITIATION AND ELONGATION AT THE HIV-1 PROMOTER

  Annual Review of Biochemistry · 1994 · https://doi.org/10.1146/annurev.bi.63.070194.003441

• Trans-activation by HIV-1 Tat via a heterologous RNA binding protein

  Cell · 1990 · https://doi.org/10.1016/0092-8674(90)90121-t

• Structure, sequence, and position of the stem-loop in tar determine transcriptional elongation by tat through the HIV-1 long terminal repeat.

  Genes & Development · 1989 · https://doi.org/10.1101/gad.3.4.547

• Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product

  Nature · 1987 · https://doi.org/10.1038/330489a0

• Human immunodeficiency virus long terminal repeat responds to T-cell activation signals.

  Proceedings of the National Academy of Sciences · 1987 · https://doi.org/10.1073/pnas.84.19.6845

• Elevated levels of mRNA can account for the trans-activation of human immunodeficiency virus.

  Proceedings of the National Academy of Sciences · 1986 · https://doi.org/10.1073/pnas.83.24.9734

• Intervening sequence of DNA identified in the structural portion of a mouse beta-globin gene.

  Proceedings of the National Academy of Sciences · 1978 · https://doi.org/10.1073/pnas.75.2.725

Current projects

No projects listed.