William F. DeGrado

Research interests

Publications

• Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity

  Nature Communications · 2017 · 10.1038/s41467-017-01447-x

• Short peptides self-assemble to produce catalytic amyloids

  Nature Chemistry · 2014 · https://doi.org/10.1038/nchem.1894

• Salt bridges: Geometrically specific, designable interactions

  Proteins Structure Function and Bioinformatics · 2010 · 10.1002/prot.22927

• Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers

  Nature · 2010 · 10.1038/nature08722

• De Novo Design of Antimicrobial Polymers, Foldamers, and Small Molecules: From Discovery to Practical Applications

  Accounts of Chemical Research · 2009 · 10.1021/ar900036b

• The Role of Hydrophobicity in the Antimicrobial and Hemolytic Activities of Polymethacrylate Derivatives

  Chemistry - A European Journal · 2008 · 10.1002/chem.200801523

• Structural basis for the function and inhibition of an influenza virus proton channel

  Nature · 2008 · 10.1038/nature06528

• Foldamers as versatile frameworks for the design and evolution of function

  Nature Chemical Biology · 2007 · https://doi.org/10.1038/nchembio876

• Amphiphilic Polymethacrylate Derivatives as Antimicrobial Agents

  Journal of the American Chemical Society · 2005 · 10.1021/ja044205+

• Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs

  Current Opinion in Structural Biology · 2004 · 10.1016/j.sbi.2004.07.007

• Using Nitrile-Derivatized Amino Acids as Infrared Probes of Local Environment

  Journal of the American Chemical Society · 2002 · 10.1021/ja0285262

• De novo design of biomimetic antimicrobial polymers

  Proceedings of the National Academy of Sciences · 2002 · 10.1073/pnas.082046199

• β-Peptides: From Structure to Function

  Chemical Reviews · 2001 · https://doi.org/10.1021/cr000045i

• Asparagine-mediated self-association of a model transmembrane helix.

  Nature Structural Biology · 2000 · 10.1038/72440

• De Novo Design and Structural Characterization of Proteins and Metalloproteins

  Annual Review of Biochemistry · 1999 · 10.1146/annurev.biochem.68.1.779

• De Novo Design of Antibacterial β-Peptides

  Journal of the American Chemical Society · 1999 · 10.1021/ja992728p

• The two-dimensional IR nonlinear spectroscopy of a cyclic penta-peptide in relation to its three-dimensional structure

  Proceedings of the National Academy of Sciences · 1999 · 10.1073/pnas.96.5.2036

• A functionally defined model for the M 2 proton channel of influenza A virus suggests a mechanism for its ion selectivity

  Proceedings of the National Academy of Sciences · 1997 · 10.1073/pnas.94.21.11301

• Protein Design: A Hierarchic Approach

  Science · 1995 · 10.1126/science.270.5238.935

• Design and synthesis of multi-haem proteins

  Nature · 1994 · 10.1038/368425a0

• A Thermodynamic Scale for the Helix-Forming Tendencies of the Commonly Occurring Amino Acids

  Science · 1990 · https://doi.org/10.1126/science.2237415

• How calmodulin binds its targets: sequence independent recognition of amphiphilic α-helices

  Trends in Biochemical Sciences · 1990 · https://doi.org/10.1016/0968-0004(90)90177-d

• Protein Design, a Minimalist Approach

  Science · 1989 · 10.1126/science.2464850

• Characterization of a Helical Protein Designed from First Principles

  Science · 1988 · 10.1126/science.3043666

• Induction of peptide conformation at apolar water interfaces. 1. A study with model peptides of defined hydrophobic periodicity

  Journal of the American Chemical Society · 1985 · 10.1021/ja00311a076

Current projects

No projects listed.