Michel Mittelbronn

Research interests

Publications

• Propagative α-synuclein seeds as serum biomarkers for synucleinopathies

  Nature Medicine · 2023 · 10.1038/s41591-023-02358-9

• Sarcoma classification by DNA methylation profiling

  Nature Communications · 2021 · 10.1038/s41467-020-20603-4

• Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology

  Acta Neuropathologica · 2020 · https://doi.org/10.1007/s00401-020-02226-7

• Parkinson’s disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions

  BMC Biology · 2020 · 10.1186/s12915-020-00775-7

• Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway

  Autophagy · 2019 · https://doi.org/10.1080/15548627.2019.1687213

• DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis

  The Lancet Oncology · 2017 · https://doi.org/10.1016/s1470-2045(17)30155-9

• Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function

  Circulation · 2017 · 10.1161/circulationaha.116.026991

• Methylation-based classification of benign and malignant peripheral nerve sheath tumors

  Acta Neuropathologica · 2016 · 10.1007/s00401-016-1540-6

• Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities

  Acta Neuropathologica · 2015 · 10.1007/s00401-015-1454-8

• ErbB2/HER2-Specific NK Cells for Targeted Therapy of Glioblastoma

  JNCI Journal of the National Cancer Institute · 2015 · 10.1093/jnci/djv375

• Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity

  Acta Neuropathologica · 2015 · 10.1007/s00401-015-1493-1

• ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an “integrated” diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma

  Acta Neuropathologica · 2014 · 10.1007/s00401-014-1370-3

• Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors

  Human Molecular Genetics · 2013 · 10.1093/hmg/ddt338

• Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system

  Acta Neuropathologica · 2013 · 10.1007/s00401-013-1195-5

• Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia

  Nature Medicine · 2012 · 10.1038/nm.2728

• The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury

  Acta Neuropathologica · 2012 · 10.1007/s00401-012-1076-3

• Molecular Classification of Low-Grade Diffuse Gliomas

  American Journal Of Pathology · 2010 · 10.2353/ajpath.2010.100680

• Cardioprotection by Ecto-5′-Nucleotidase (CD73) and A 2B Adenosine Receptors

  Circulation · 2007 · 10.1161/circulationaha.106.669697

• CD39/Ectonucleoside Triphosphate Diphosphohydrolase 1 Provides Myocardial Protection During Cardiac Ischemia/Reperfusion Injury

  Circulation · 2007 · 10.1161/circulationaha.107.690180

• Identification of Ectonucleotidases CD39 and CD73 in Innate Protection during Acute Lung Injury

  The Journal of Immunology · 2007 · 10.4049/jimmunol.178.12.8127

• Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude

  Acta Neuropathologica · 2001 · 10.1007/s004010000284

Current projects

No projects listed.