Margaret A. Goodell

Research interests

Publications

• Ageing and rejuvenation of tissue stem cells and their niches

  Nature Reviews Molecular Cell Biology · 2022 · https://doi.org/10.1038/s41580-022-00510-w

• PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy

  Cell stem cell · 2018 · https://doi.org/10.1016/j.stem.2018.10.004

• Stem cells and healthy aging

  Science · 2015 · https://doi.org/10.1126/science.aab3388

• DNMT3A in haematological malignancies

  Nature reviews. Cancer · 2015 · https://doi.org/10.1038/nrc3895

• Dnmt3a and Dnmt3b Have Overlapping and Distinct Functions in Hematopoietic Stem Cells

  Cell stem cell · 2014 · https://doi.org/10.1016/j.stem.2014.06.018

• mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert

  Nature · 2014 · https://doi.org/10.1038/nature13255

• Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal

  Cell stem cell · 2014 · https://doi.org/10.1016/j.stem.2014.03.002

• Inflammatory signals regulate hematopoietic stem cells

  Trends in Immunology · 2011 · https://doi.org/10.1016/j.it.2010.12.003

• Dnmt3a is essential for hematopoietic stem cell differentiation

  Nature Genetics · 2011 · https://doi.org/10.1038/ng.1009

• Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response

  Nature reviews. Immunology · 2011 · https://doi.org/10.1038/nri3062

• Distinct Hematopoietic Stem Cell Subtypes Are Differentially Regulated by TGF-β1

  Cell stem cell · 2010 · https://doi.org/10.1016/j.stem.2010.02.002

• Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection

  Nature · 2010 · https://doi.org/10.1038/nature09135

• Mouse hematopoietic stem cell identification and analysis

  Cytometry Part A · 2008 · https://doi.org/10.1002/cyto.a.20674

• Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation

  PLoS Biology · 2007 · https://doi.org/10.1371/journal.pbio.0050201

• A distinct “side population” of cells with high drug efflux capacity in human tumor cells

  Proceedings of the National Academy of Sciences · 2004 · https://doi.org/10.1073/pnas.0400067101

• Molecular Signatures of Proliferation and Quiescence in Hematopoietic Stem Cells

  PLoS Biology · 2004 · https://doi.org/10.1371/journal.pbio.0020301

• Single hematopoietic stem cells generate skeletal muscle through myeloid intermediates

  Nature Medicine · 2003 · https://doi.org/10.1038/nm963

• Sca-1pos Cells in the Mouse Mammary Gland Represent an Enriched Progenitor Cell Population

  Developmental Biology · 2002 · https://doi.org/10.1006/dbio.2002.0625

• Muscle-derived hematopoietic stem cells are hematopoietic in origin

  Proceedings of the National Academy of Sciences · 2002 · https://doi.org/10.1073/pnas.032438799

• Failure of Bone Marrow Cells to Transdifferentiate into Neural Cells in Vivo

  Science · 2002 · https://doi.org/10.1126/science.297.5585.1299

• Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells

  Journal of Clinical Investigation · 2001 · https://doi.org/10.1172/jci12150

• Hematopoietic potential of stem cells isolated from murine skeletal muscle

  Proceedings of the National Academy of Sciences · 1999 · https://doi.org/10.1073/pnas.96.25.14482

• Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species

  Nature Medicine · 1997 · https://doi.org/10.1038/nm1297-1337

• Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo.

  The Journal of Experimental Medicine · 1996 · https://doi.org/10.1084/jem.183.4.1797

• Effects of an Rb mutation in the mouse

  Nature · 1992 · https://doi.org/10.1038/359295a0

Current projects

No projects listed.