Lai Guan Ng

Research interests

Publications

• Deterministic reprogramming of neutrophils within tumors

  Science · 2024 · https://doi.org/10.1126/science.adf6493

• iPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer

  Nature · 2023 · https://doi.org/10.1038/s41586-023-06713-1

• Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress

  Nature Immunology · 2022 · https://doi.org/10.1038/s41590-022-01311-1

• Patients with COVID-19: in the dark-NETs of neutrophils

  Cell Death and Differentiation · 2021 · https://doi.org/10.1038/s41418-021-00805-z

• A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.08.031

• Deciphering human macrophage development at single-cell resolution

  Nature · 2020 · https://doi.org/10.1038/s41586-020-2316-7

• Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.08.002

• Co-option of Neutrophil Fates by Tissue Environments

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.10.003

• Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor

  Immunity · 2020 · https://doi.org/10.1016/j.immuni.2020.06.005

• A Neutrophil Timer Coordinates Immune Defense and Vascular Protection

  Immunity · 2019 · https://doi.org/10.1016/j.immuni.2019.01.002

• Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells

  Cell · 2019 · https://doi.org/10.1016/j.cell.2019.08.009

• Heterogeneity of neutrophils

  Nature reviews. Immunology · 2019 · https://doi.org/10.1038/s41577-019-0141-8

• Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

  Science · 2019 · https://doi.org/10.1126/science.aau0964

• Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions

  Immunity · 2018 · 10.1016/j.immuni.2018.02.002

• Neutrophils instruct homeostatic and pathological states in naive tissues

  The Journal of Experimental Medicine · 2018 · https://doi.org/10.1084/jem.20181468

• Dimensionality reduction for visualizing single-cell data using UMAP

  Nature Biotechnology · 2018 · 10.1038/nbt.4314

• Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function

  Immunity · 2017 · https://doi.org/10.1016/j.immuni.2017.06.017

• CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses

  The Journal of Experimental Medicine · 2016 · https://doi.org/10.1084/jem.20160800

• C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

  Immunity · 2015 · 10.1016/j.immuni.2015.03.011

• Biocompatible Nanoparticles Based on Diketo‐Pyrrolo‐Pyrrole (DPP) with Aggregation‐Induced Red/NIR Emission for In Vivo Two‐Photon Fluorescence Imaging

  Advanced Functional Materials · 2015 · https://doi.org/10.1002/adfm.201500010

• Plasmodium vivax: restricted tropism and rapid remodeling of CD71-positive reticulocytes

  Blood · 2014 · https://doi.org/10.1182/blood-2014-08-596015

• The gut microbiota influences blood-brain barrier permeability in mice

  Science Translational Medicine · 2014 · https://doi.org/10.1126/scitranslmed.3009759

• IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses

  Immunity · 2013 · 10.1016/j.immuni.2013.04.011

• Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow

  The Journal of Experimental Medicine · 2013 · https://doi.org/10.1084/jem.20130056

• Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages

  The Journal of Experimental Medicine · 2012 · 10.1084/jem.20120340

• Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

  Science · 2010 · 10.1126/science.1194637

Current projects

No projects listed.