Jonathan Z. Long

Research interests

Publications

• An exercise-inducible metabolite that suppresses feeding and obesity

  Nature · 2022 · 10.1038/s41586-022-04828-5

• H+ transport is an integral function of the mitochondrial ADP/ATP carrier

  Nature · 2019 · 10.1038/s41586-019-1400-3

• The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria

  Cell · 2016 · 10.1016/j.cell.2016.05.071

• A Smooth Muscle-Like Origin for Beige Adipocytes

  Cell Metabolism · 2014 · 10.1016/j.cmet.2014.03.025

• Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis

  Cell · 2014 · https://doi.org/10.1016/j.cell.2014.03.065

• ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC

  Proceedings of the National Academy of Sciences · 2013 · 10.1073/pnas.1217121110

• A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

  Nature · 2012 · https://doi.org/10.1038/nature10777

• Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

  Science · 2011 · https://doi.org/10.1126/science.1209200

• Monoacylglycerol Lipase Exerts Dual Control over Endocannabinoid and Fatty Acid Pathways to Support Prostate Cancer

  Chemistry & Biology · 2011 · 10.1016/j.chembiol.2011.05.009

• The Metabolic Serine Hydrolases and Their Functions in Mammalian Physiology and Disease

  Chemical Reviews · 2011 · 10.1021/cr200075y

• The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

  Nature Neuroscience · 2010 · 10.1038/nn.2601

• Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

  Nature Neuroscience · 2010 · https://doi.org/10.1038/nn.2616

• Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

  Chemistry & Biology · 2009 · 10.1016/j.chembiol.2009.02.013

• Characterization of Monoacylglycerol Lipase Inhibition Reveals Differences in Central and Peripheral Endocannabinoid Metabolism

  Chemistry & Biology · 2009 · 10.1016/j.chembiol.2009.05.009

• Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo

  Proceedings of the National Academy of Sciences · 2009 · 10.1073/pnas.0909411106

• Blockade of Endocannabinoid-Degrading Enzymes Attenuates Neuropathic Pain

  Journal of Pharmacology and Experimental Therapeutics · 2009 · 10.1124/jpet.109.155465

• Blockade of 2-Arachidonoylglycerol Hydrolysis by Selective Monoacylglycerol Lipase Inhibitor 4-Nitrophenyl 4-(Dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances Retrograde Endocannabinoid Signaling

  Journal of Pharmacology and Experimental Therapeutics · 2009 · 10.1124/jpet.109.158162

• Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

  Cell · 2009 · https://doi.org/10.1016/j.cell.2009.11.027

• Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

  Nature Chemical Biology · 2008 · 10.1038/nchembio.129

Current projects

No projects listed.