Thomas D. Schmittgen

Research interests

Publications

• MiRNA199a-3p suppresses tumor growth, migration, invasion and angiogenesis in hepatocellular carcinoma by targeting VEGFA, VEGFR1, VEGFR2, HGF and MMP2

  Cell Death and Disease · 2017 · 10.1038/cddis.2017.123

• Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells

  Journal of Extracellular Vesicles · 2017 · 10.1080/20013078.2017.1324730

• miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor

  Biochemical and Biophysical Research Communications · 2011 · 10.1016/j.bbrc.2011.02.065

• miR-221 Silencing Blocks Hepatocellular Carcinoma and Promotes Survival

  Cancer Research · 2011 · 10.1158/0008-5472.can-11-1144

• Role of MicroRNA-155 at Early Stages of Hepatocarcinogenesis Induced by Choline-Deficient and Amino Acid–Defined Diet in C57BL/6 Mice†

  Hepatology · 2009 · 10.1002/hep.23100

• Antisense Inhibition of microRNA-21 or -221 Arrests Cell Cycle, Induces Apoptosis, and Sensitizes the Effects of Gemcitabine in Pancreatic Adenocarcinoma

  Pancreas · 2009 · 10.1097/mpa.0b013e3181ba82e1

• MicroRNA-34a Inhibits Glioblastoma Growth by Targeting Multiple Oncogenes

  Cancer Research · 2009 · 10.1158/0008-5472.can-09-0529

• Analyzing real-time PCR data by the comparative CT method

  Nature Protocols · 2008 · https://doi.org/10.1038/nprot.2008.73

• Detection of microRNA Expression in Human Peripheral Blood Microvesicles

  PLoS ONE · 2008 · https://doi.org/10.1371/journal.pone.0003694

• Association of MicroRNA Expression in Hepatocellular Carcinomas with Hepatitis Infection, Cirrhosis, and Patient Survival

  Clinical Cancer Research · 2008 · 10.1158/1078-0432.ccr-07-0523

• RETRACTED: Methylation Mediated Silencing of MicroRNA-1 Gene and Its Role in Hepatocellular Carcinogenesis

  Cancer Research · 2008 · 10.1158/0008-5472.can-07-6655

• MicroRNAs modulate the chemosensitivity of tumor cells

  Molecular Cancer Therapeutics · 2008 · 10.1158/1535-7163.mct-07-0573

• Ultraconserved Regions Encoding ncRNAs Are Altered in Human Leukemias and Carcinomas

  Cancer Cell · 2007 · 10.1016/j.ccr.2007.07.027

• Real-time PCR quantification of precursor and mature microRNA

  Methods · 2007 · 10.1016/j.ymeth.2007.09.006

• The Human Angiotensin II Type 1 Receptor +1166 A/C Polymorphism Attenuates MicroRNA-155 Binding

  Journal of Biological Chemistry · 2007 · 10.1074/jbc.m701050200

• MicroRNAs and cancer: Profile, profile, profile

  International Journal of Cancer · 2007 · 10.1002/ijc.23343

• Systematic evaluation of microRNA processing patterns in tissues, cell lines, and tumors

  RNA · 2007 · 10.1261/rna.804508

• Expression profiling identifies microRNA signature in pancreatic cancer

  International Journal of Cancer · 2006 · 10.1002/ijc.22394

• Involvement of Human Micro-RNA in Growth and Response to Chemotherapy in Human Cholangiocarcinoma Cell Lines

  Gastroenterology · 2006 · https://doi.org/10.1053/j.gastro.2006.02.057

• MicroRNA-155 Regulates Human Angiotensin II Type 1 Receptor Expression in Fibroblasts

  Journal of Biological Chemistry · 2006 · 10.1074/jbc.m601496200

• A high-throughput method to monitor the expression of microRNA precursors

  Nucleic Acids Research · 2004 · 10.1093/nar/gnh040

• Real-Time Quantitative PCR

  Methods · 2001 · 10.1006/meth.2001.1260

• Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

  Methods · 2001 · https://doi.org/10.1006/meth.2001.1262

• Quantitative Reverse Transcription–Polymerase Chain Reaction to Study mRNA Decay: Comparison of Endpoint and Real-Time Methods

  Analytical Biochemistry · 2000 · https://doi.org/10.1006/abio.2000.4753

• Effect of experimental treatment on housekeeping gene expression: validation by real-time, quantitative RT-PCR

  Journal of Biochemical and Biophysical Methods · 2000 · https://doi.org/10.1016/s0165-022x(00)00129-9

Current projects

No projects listed.