Leendert H. J. Looijenga

Research interests

Publications

• Human germ cell tumours from a developmental perspective

  Nature reviews. Cancer · 2019 · 10.1038/s41568-019-0178-9

• Testicular cancer

  Nature Reviews Disease Primers · 2018 · 10.1038/s41572-018-0029-0

• WHO Classification of of Tumours of the Urinary System and Male Genital Organs

  Journal · 2016

• Disorders of sex development: insights from targeted gene sequencing of a large international patient cohort

  Genome biology · 2016 · 10.1186/s13059-016-1105-y

• Global Disorders of Sex Development Update since 2006: Perceptions, Approach and Care

  Hormone Research in Paediatrics · 2016 · https://doi.org/10.1159/000442975

• Maintaining success, reducing treatment burden, focusing on survivorship: highlights from the third European consensus conference on diagnosis and treatment of germ-cell cancer

  Annals of Oncology · 2012 · 10.1093/annonc/mds579

• Aberrant p53 protein expression is associated with an increased risk of neoplastic progression in patients with Barrett's oesophagus

  Gut · 2012 · 10.1136/gutjnl-2012-303594

• Gonadal Pathology and Tumor Risk in Relation to Clinical Characteristics in Patients with 45,X/46,XY Mosaicism

  The Journal of Clinical Endocrinology & Metabolism · 2011 · https://doi.org/10.1210/jc.2011-0232

• National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Use of Tumor Markers in Testicular, Prostate, Colorectal, Breast, and Ovarian Cancers

  Clinical Chemistry · 2008 · https://doi.org/10.1373/clinchem.2008.105601

• Differential expression of SOX17 and SOX2 in germ cells and stem cells has biological and clinical implications

  The Journal of Pathology · 2008 · 10.1002/path.2332

• Tumor risk in disorders of sex development (DSD)

  Best Practice & Research Clinical Endocrinology & Metabolism · 2007 · 10.1016/j.beem.2007.05.001

• High‐throughput microRNAome analysis in human germ cell tumours

  The Journal of Pathology · 2007 · 10.1002/path.2230

• Patterns of somatic mutation in human cancer genomes

  Nature · 2007 · https://doi.org/10.1038/nature05610

• Germ Cell Tumors in the Intersex Gonad: Old Paths, New Directions, Moving Frontiers

  Endocrine Reviews · 2006 · 10.1210/er.2006-0005

• A Genetic Screen Implicates miRNA-372 and miRNA-373 As Oncogenes in Testicular Germ Cell Tumors

  Cell · 2006 · https://doi.org/10.1016/j.cell.2006.02.037

• OCT4: biological functions and clinical applications as a marker of germ cell neoplasia

  The Journal of Pathology · 2006 · 10.1002/path.2105

• Gonadoblastoma Arising in Undifferentiated Gonadal Tissue within Dysgenetic Gonads

  The Journal of Clinical Endocrinology & Metabolism · 2006 · 10.1210/jc.2005-2554

• The pluripotency homeobox gene NANOG is expressed in human germ cell tumors

  Cancer · 2005 · 10.1002/cncr.21435

• A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer

  Nature Genetics · 2005 · 10.1038/ng1571

• Testicular germ-cell tumours in a broader perspective

  Nature reviews. Cancer · 2005 · https://doi.org/10.1038/nrc1568

• Somatic Mutations of the Protein Kinase Gene Family in Human Lung Cancer

  Cancer Research · 2005 · 10.1158/0008-5472.can-05-1855

• Intragenic ERBB2 kinase mutations in tumours

  Nature · 2004 · 10.1038/431525b

• Pathobiological implications of the expression of markers of testicular carcinoma in situ by fetal germ cells

  The Journal of Pathology · 2004 · 10.1002/path.1587

• POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors.

  PubMed · 2003

• Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas

  Oncogene · 2002 · 10.1038/sj.onc.1205505

• Extensive genetic alterations of the HLA region, including homozygous deletions of HLA class II genes in B-cell lymphomas arising in immune-privileged sites

  Blood · 2000 · 10.1182/blood.v96.10.3569

Current projects

No projects listed.