Albert J. R. Heck

Research interests

Publications

• High-Resolution Native Mass Spectrometry

  Chemical Reviews · 2021 · https://doi.org/10.1021/acs.chemrev.1c00212

• Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

  Nature Methods · 2019 · https://doi.org/10.1038/s41592-019-0459-y

• Identification of CMTM6 and CMTM4 as PD-L1 protein regulators

  Nature · 2017 · https://doi.org/10.1038/nature23669

• Native Mass Spectrometry: What is in the Name?

  Journal of the American Society for Mass Spectrometry · 2016 · https://doi.org/10.1007/s13361-016-1545-3

• Six alternative proteases for mass spectrometry–based proteomics beyond trypsin

  Nature Protocols · 2016 · https://doi.org/10.1038/nprot.2016.057

• Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry

  Nature Methods · 2015 · https://doi.org/10.1038/nmeth.3603

• NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling

  Molecular Cell · 2015 · https://doi.org/10.1016/j.molcel.2015.07.032

• Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

  Science · 2014 · https://doi.org/10.1126/science.1248943

• The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

  Nature Methods · 2013 · https://doi.org/10.1038/nmeth.2557

• Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex

  Cell · 2012 · https://doi.org/10.1016/j.cell.2012.05.002

• Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

  Nature · 2012 · https://doi.org/10.1038/nature11308

• The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

  The EMBO Journal · 2012 · https://doi.org/10.1038/emboj.2012.166

• Next-generation proteomics: towards an integrative view of proteome dynamics

  Nature Reviews Genetics · 2012 · https://doi.org/10.1038/nrg3356

• Toward a Comprehensive Characterization of a Human Cancer Cell Phosphoproteome

  Journal of Proteome Research · 2012 · https://doi.org/10.1021/pr300630k

• Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

  Nature · 2011 · https://doi.org/10.1038/nature10337

• Structural basis for CRISPR RNA-guided DNA recognition by Cascade

  Nature Structural & Molecular Biology · 2011 · https://doi.org/10.1038/nsmb.2019

• RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions

  Proceedings of the National Academy of Sciences · 2011 · https://doi.org/10.1073/pnas.1102716108

• Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics

  Nature Protocols · 2009 · https://doi.org/10.1038/nprot.2009.21

• Ion mobility mass spectrometry of proteins and proteinassemblies

  Chemical Society Reviews · 2009 · https://doi.org/10.1039/b914002f

• Native mass spectrometry: a bridge between interactomics and structural biology

  Nature Methods · 2008 · https://doi.org/10.1038/nmeth.1265

• Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7

  The Journal of Cell Biology · 2008 · https://doi.org/10.1083/jcb.200804048

• The minimum information about a proteomics experiment (MIAPE)

  Nature Biotechnology · 2007 · https://doi.org/10.1038/nbt1329

• Quantitative Phosphoproteomics of Early Elicitor Signaling in Arabidopsis

  Molecular & Cellular Proteomics · 2007 · https://doi.org/10.1074/mcp.m600429-mcp200

• Investigation of intact protein complexes by mass spectrometry

  Mass Spectrometry Reviews · 2004 · https://doi.org/10.1002/mas.10081

• Selective Isolation at the Femtomole Level of Phosphopeptides from Proteolytic Digests Using 2D-NanoLC-ESI-MS/MS and Titanium Oxide Precolumns

  Analytical Chemistry · 2004 · https://doi.org/10.1021/ac0498617

Current projects

No projects listed.