Shahin Rafii

Research interests

Publications

• Angiocrine functions of organ-specific endothelial cells

  Nature · 2016 · https://doi.org/10.1038/nature17040

• Distinct bone marrow blood vessels differentially regulate haematopoiesis

  Nature · 2016 · https://doi.org/10.1038/nature17624

• Molecular Signatures of Tissue-Specific Microvascular Endothelial Cell Heterogeneity in Organ Maintenance and Regeneration

  Developmental Cell · 2013 · https://doi.org/10.1016/j.devcel.2013.06.017

• Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis

  Nature · 2013 · https://doi.org/10.1038/nature12681

• Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration

  Nature · 2010 · https://doi.org/10.1038/nature09493

• Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

  Cell · 2010 · https://doi.org/10.1016/j.cell.2010.01.003

• Endothelial Cells Are Essential for the Self-Renewal and Repopulation of Notch-Dependent Hematopoietic Stem Cells

  Cell stem cell · 2010 · https://doi.org/10.1016/j.stem.2010.02.001

• Engraftment and Reconstitution of Hematopoiesis Is Dependent on VEGFR2-Mediated Regeneration of Sinusoidal Endothelial Cells

  Cell stem cell · 2009 · https://doi.org/10.1016/j.stem.2009.01.006

• CD133 expression is not restricted to stem cells, and both CD133+ and CD133– metastatic colon cancer cells initiate tumors

  Journal of Clinical Investigation · 2008 · https://doi.org/10.1172/jci34401

• Preparing the “Soil”: The Premetastatic Niche

  Cancer Research · 2006 · https://doi.org/10.1158/0008-5472.can-06-2407

• Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes

  Nature Medicine · 2006 · https://doi.org/10.1038/nm1400

• VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

  Nature · 2005 · https://doi.org/10.1038/nature04186

• Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis

  Science · 2003 · https://doi.org/10.1126/science.1082504

• Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration

  Nature Medicine · 2003 · https://doi.org/10.1038/nm0603-702

• Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis

  Nature Medicine · 2003 · https://doi.org/10.1038/nm973

• Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-Ligand

  Cell · 2002 · https://doi.org/10.1016/s0092-8674(02)00754-7

• Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?

  Nature reviews. Cancer · 2002 · https://doi.org/10.1038/nrc925

• Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1+ stem cells from bone-marrow microenvironment

  Nature Medicine · 2002 · https://doi.org/10.1038/nm740

• Vascular Trauma Induces Rapid but Transient Mobilization of VEGFR2 + AC133 + Endothelial Precursor Cells

  Circulation Research · 2001 · https://doi.org/10.1161/01.res.88.2.167

• Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

  Nature Medicine · 2001 · https://doi.org/10.1038/nm1101-1194

• Vascular Endothelial Growth Factor and Angiopoietin-1 Stimulate Postnatal Hematopoiesis by Recruitment of Vasculogenic and Hematopoietic Stem Cells

  The Journal of Experimental Medicine · 2001 · https://doi.org/10.1084/jem.193.9.1005

• Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors

  Blood · 2000 · https://doi.org/10.1182/blood.v95.3.952.003k27_952_958

• Evidence for Circulating Bone Marrow-Derived Endothelial Cells

  Blood · 1998 · https://doi.org/10.1182/blood.v92.2.362

• The Chemokine Receptor CXCR-4 Is Expressed on CD34+Hematopoietic Progenitors and Leukemic Cells and Mediates Transendothelial Migration Induced by Stromal Cell-Derived Factor-1

  Blood · 1998 · https://doi.org/10.1182/blood.v91.12.4523

• Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets

  Proceedings of the National Academy of Sciences · 1997 · https://doi.org/10.1073/pnas.94.2.663

Current projects

No projects listed.