Michael T. Longaker

Research interests

Publications

• Wound healing, fibroblast heterogeneity, and fibrosis

  Cell stem cell · 2022 · 10.1016/j.stem.2022.07.006

• Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring

  Science · 2021 · 10.1126/science.aba2374

• Mechanisms of bone development and repair

  Nature Reviews Molecular Cell Biology · 2020 · https://doi.org/10.1038/s41580-020-00279-w

• Identification of the Human Skeletal Stem Cell

  Cell · 2018 · 10.1016/j.cell.2018.07.029

• Identification and Specification of the Mouse Skeletal Stem Cell

  Cell · 2015 · https://doi.org/10.1016/j.cell.2014.12.002

• Identification and isolation of a dermal lineage with intrinsic fibrogenic potential

  Science · 2015 · https://doi.org/10.1126/science.aaa2151

• The Role of Hypoxia-Inducible Factor in Wound Healing

  Advances in Wound Care · 2014 · 10.1089/wound.2013.0520

• Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells

  Cell stem cell · 2013 · 10.1016/j.stem.2012.10.010

• Patient-Specific Induced Pluripotent Stem Cells as a Model for Familial Dilated Cardiomyopathy

  Science Translational Medicine · 2012 · 10.1126/scitranslmed.3003552

• Enhancement of mesenchymal stem cell angiogenic capacity and stemness by a biomimetic hydrogel scaffold

  Biomaterials · 2011 · 10.1016/j.biomaterials.2011.09.041

• Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tip

  Nature · 2011 · 10.1038/nature10346

• Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling

  Nature Medicine · 2011 · 10.1038/nm.2574

• Surgical Approaches to Create Murine Models of Human Wound Healing

  BioMed Research International · 2010 · 10.1155/2011/969618

• Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271

  Nature · 2010 · 10.1038/nature09161

• Scarless Fetal Wound Healing: A Basic Science Review

  Plastic & Reconstructive Surgery · 2010 · 10.1097/prs.0b013e3181eae781

• A nonviral minicircle vector for deriving human iPS cells

  Nature Methods · 2010 · https://doi.org/10.1038/nmeth.1426

• Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells

  Proceedings of the National Academy of Sciences · 2009 · 10.1073/pnas.0908450106

• Human skin wounds: A major and snowballing threat to public health and the economy

  Wound Repair and Regeneration · 2009 · https://doi.org/10.1111/j.1524-475x.2009.00543.x

• Wound repair and regeneration

  Nature · 2008 · 10.1038/nature07039

• Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis

  The FASEB Journal · 2007 · 10.1096/fj.07-8218com

• Gene Expression Programs in Response to Hypoxia: Cell Type Specificity and Prognostic Significance in Human Cancers

  PLoS Medicine · 2006 · 10.1371/journal.pmed.0030047

• Adipose-derived adult stromal cells heal critical-size mouse calvarial defects

  Nature Biotechnology · 2004 · 10.1038/nbt958

• Regulation of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes.

  Journal of Biological Chemistry · 1995 · 10.1074/jbc.270.21.12607

• The Function of KGF in Morphogenesis of Epithelium and Reepithelialization of Wounds

  Science · 1994 · 10.1126/science.7973639

• Large induction of keratinocyte growth factor expression in the dermis during wound healing.

  Proceedings of the National Academy of Sciences · 1992 · 10.1073/pnas.89.15.6896

Current projects

No projects listed.