Aaron M. Newman

Research interests

Publications

• Profiling cell identity and tissue architecture with single-cell and spatial transcriptomics

  Nature Reviews Molecular Cell Biology · 2024 · 10.1038/s41580-024-00768-2

• T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma

  Nature Medicine · 2022 · 10.1038/s41591-021-01623-z

• The landscape of tumor cell states and ecosystems in diffuse large B cell lymphoma

  Cancer Cell · 2021 · 10.1016/j.ccell.2021.08.011

• Atlas of clinically distinct cell states and ecosystems across human solid tumors

  Cell · 2021 · 10.1016/j.cell.2021.09.014

• Profiling Cell Type Abundance and Expression in Bulk Tissues with CIBERSORTx

  Methods in molecular biology · 2020 · 10.1007/978-1-0716-0301-7_7

• Single-cell transcriptional diversity is a hallmark of developmental potential

  Science · 2020 · https://doi.org/10.1126/science.aax0249

• Noninvasive Early Identification of Therapeutic Benefit from Immune Checkpoint Inhibition

  Cell · 2020 · 10.1016/j.cell.2020.09.001

• Circulating Tumor DNA Analysis for Detection of Minimal Residual Disease After Chemoradiotherapy for Localized Esophageal Cancer

  Gastroenterology · 2019 · 10.1053/j.gastro.2019.10.039

• Determining cell type abundance and expression from bulk tissues with digital cytometry

  Nature Biotechnology · 2019 · https://doi.org/10.1038/s41587-019-0114-2

• The Immune Landscape of Cancer

  Immunity · 2018 · https://doi.org/10.1016/j.immuni.2018.03.023

• Profiling Tumor Infiltrating Immune Cells with CIBERSORT

  Methods in molecular biology · 2018 · https://doi.org/10.1007/978-1-4939-7493-1_12

• Circulating Tumor DNA Measurements As Early Outcome Predictors in Diffuse Large B-Cell Lymphoma

  Journal of Clinical Oncology · 2018 · 10.1200/jco.2018.78.5246

• Early B cell changes predict autoimmunity following combination immune checkpoint blockade

  Journal of Clinical Investigation · 2018 · 10.1172/jci96798

• Early Detection of Molecular Residual Disease in Localized Lung Cancer by Circulating Tumor DNA Profiling

  Cancer Discovery · 2017 · https://doi.org/10.1158/2159-8290.cd-17-0716

• Role of KEAP1 / NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance

  Cancer Discovery · 2016 · 10.1158/2159-8290.cd-16-0127

• Circulating tumour DNA profiling reveals heterogeneity of EGFR inhibitor resistance mechanisms in lung cancer patients

  Nature Communications · 2016 · 10.1038/ncomms11815

• Distinct biological subtypes and patterns of genome evolution in lymphoma revealed by circulating tumor DNA

  Science Translational Medicine · 2016 · 10.1126/scitranslmed.aai8545

• Integrated digital error suppression for improved detection of circulating tumor DNA

  Nature Biotechnology · 2016 · 10.1038/nbt.3520

• The prognostic landscape of genes and infiltrating immune cells across human cancers

  Nature Medicine · 2015 · 10.1038/nm.3909

• Identification and isolation of a dermal lineage with intrinsic fibrogenic potential

  Science · 2015 · 10.1126/science.aaa2151

• Robust enumeration of cell subsets from tissue expression profiles

  Nature Methods · 2015 · 10.1038/nmeth.3337

• FACTERA: a practical method for the discovery of genomic rearrangements at breakpoint resolution

  Bioinformatics · 2014 · 10.1093/bioinformatics/btu549

• An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage

  Nature Medicine · 2014 · 10.1038/nm.3519

• clusterMaker: a multi-algorithm clustering plugin for Cytoscape

  BMC Bioinformatics · 2011 · 10.1186/1471-2105-12-436

Current projects

No projects listed.