Christine Desmedt

Research interests

Publications

• A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer

  Nature Medicine · 2021 · https://doi.org/10.1038/s41591-021-01323-8

• Unraveling Triple-Negative Breast Cancer Tumor Microenvironment Heterogeneity: Towards an Optimized Treatment Approach

  JNCI Journal of the National Cancer Institute · 2019 · https://doi.org/10.1093/jnci/djz208

• Genomic Evolution of Breast Cancer Metastasis and Relapse

  Cancer Cell · 2017 · https://doi.org/10.1016/j.ccell.2017.07.005

• Genomic Characterization of Primary Invasive Lobular Breast Cancer

  Journal of Clinical Oncology · 2016 · https://doi.org/10.1200/jco.2015.64.0334

• Landscape of somatic mutations in 560 breast cancer whole-genome sequences

  Nature · 2016 · https://doi.org/10.1038/nature17676

• Genomic Characterization of Primary Invasive Lobular Breast Cancer

  Journal of Clinical Oncology · 2016 · https://doi.org/10.1200/jco.2015.64.0334

• Subclonal diversification of primary breast cancer revealed by multiregion sequencing

  Nature Medicine · 2015 · https://doi.org/10.1038/nm.3886

• Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome

  Cell Reports · 2015 · https://doi.org/10.1016/j.celrep.2015.09.032

• Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

  Science · 2014 · https://doi.org/10.1126/science.1251343

• Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: results from the FinHER trial

  Annals of Oncology · 2014 · https://doi.org/10.1093/annonc/mdu112

• CD4+ follicular helper T cell infiltration predicts breast cancer survival

  Journal of Clinical Investigation · 2013 · 10.1172/jci67428

• Signatures of mutational processes in human cancer

  Nature · 2013 · 10.1038/nature12477

• Gene Modules and Response to Neoadjuvant Chemotherapy in Breast Cancer Subtypes: A Pooled Analysis

  Journal of Clinical Oncology · 2012 · https://doi.org/10.1200/jco.2011.39.5624

• The landscape of cancer genes and mutational processes in breast cancer

  Nature · 2012 · 10.1038/nature11017

• A Three-Gene Model to Robustly Identify Breast Cancer Molecular Subtypes

  JNCI Journal of the National Cancer Institute · 2012 · https://doi.org/10.1093/jnci/djr545

• Global MicroRNA Expression Profiling Identifies MiR-210 Associated with Tumor Proliferation, Invasion and Poor Clinical Outcome in Breast Cancer

  PLoS ONE · 2011 · https://doi.org/10.1371/journal.pone.0020980

• DNA methylation profiling reveals a predominant immune component in breast cancers

  EMBO Molecular Medicine · 2011 · https://doi.org/10.1002/emmm.201100801

• Genomic Index of Sensitivity to Endocrine Therapy for Breast Cancer

  Journal of Clinical Oncology · 2010 · https://doi.org/10.1200/jco.2010.28.4273

• Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer

  Nature Medicine · 2010 · https://doi.org/10.1038/nm.2090

• Biological Processes Associated with Breast Cancer Clinical Outcome Depend on the Molecular Subtypes

  Clinical Cancer Research · 2008 · https://doi.org/10.1158/1078-0432.ccr-07-4756

• Predicting prognosis using molecular profiling in estrogen receptor-positive breast cancer treated with tamoxifen

  BMC Genomics · 2008 · https://doi.org/10.1186/1471-2164-9-239

• A comparative study of survival models for breast cancer prognostication based on microarray data: does a single gene beat them all?

  Bioinformatics · 2008 · https://doi.org/10.1093/bioinformatics/btn374

• Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures

  Breast Cancer Research · 2008 · https://doi.org/10.1186/bcr2124

• Strong Time Dependence of the 76-Gene Prognostic Signature for Node-Negative Breast Cancer Patients in the TRANSBIG Multicenter Independent Validation Series

  Clinical Cancer Research · 2007 · 10.1158/1078-0432.ccr-06-2765

• Definition of Clinically Distinct Molecular Subtypes in Estrogen Receptor–Positive Breast Carcinomas Through Genomic Grade

  Journal of Clinical Oncology · 2007 · https://doi.org/10.1200/jco.2006.07.1522

• Gene Expression Profiling in Breast Cancer: Understanding the Molecular Basis of Histologic Grade To Improve Prognosis

  JNCI Journal of the National Cancer Institute · 2006 · 10.1093/jnci/djj052

Current projects

No projects listed.