Kian Fan Chung

Research interests

Publications

• IL-17–high asthma with features of a psoriasis immunophenotype

  Journal of Allergy and Clinical Immunology · 2019 · https://doi.org/10.1016/j.jaci.2019.03.027

• Prevalence, risk factors, and management of asthma in China: a national cross-sectional study

  The Lancet · 2019 · https://doi.org/10.1016/s0140-6736(19)31147-x

• Functional effects of the microbiota in chronic respiratory disease

  The Lancet Respiratory Medicine · 2019 · https://doi.org/10.1016/s2213-2600(18)30510-1

• Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline

  European Respiratory Journal · 2019 · https://doi.org/10.1183/13993003.00588-2019

• IL-17–high asthma with features of a psoriasis immunophenotype

  Journal of Allergy and Clinical Immunology · 2019 · https://doi.org/10.1016/j.jaci.2019.03.027

• Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation

  Journal of Allergy and Clinical Immunology · 2018 · https://doi.org/10.1016/j.jaci.2018.05.026

• Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

  Nature Genetics · 2017 · https://doi.org/10.1038/s41588-017-0014-7

• U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics

  Journal of Allergy and Clinical Immunology · 2016 · https://doi.org/10.1016/j.jaci.2016.08.048

• Impact of air pollution on the burden of chronic respiratory diseases in China: time for urgent action

  The Lancet · 2016 · https://doi.org/10.1016/s0140-6736(16)31597-5

• The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts

  European Respiratory Journal · 2015 · https://doi.org/10.1183/13993003.00780-2015

• Oxidative stress–induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease

  Journal of Allergy and Clinical Immunology · 2015 · https://doi.org/10.1016/j.jaci.2015.01.046

• Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort

  European Respiratory Journal · 2015 · https://doi.org/10.1183/13993003.00779-2015

• Integrated care pathways for airway diseases (AIRWAYS-ICPs)

  European Respiratory Journal · 2014 · https://doi.org/10.1183/09031936.00014614

• International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

  European Respiratory Journal · 2013 · https://doi.org/10.1183/09031936.00202013

• Systems medicine and integrated care to combat chronic noncommunicable diseases

  Genome Medicine · 2011 · https://doi.org/10.1186/gm259

• Diagnosis and definition of severe refractory asthma: an international consensus statement from the Innovative Medicine Initiative (IMI)

  Thorax · 2010 · https://doi.org/10.1136/thx.2010.153643

• Uniform definition of asthma severity, control, and exacerbations: Document presented for the World Health Organization Consultation on Severe Asthma

  Journal of Allergy and Clinical Immunology · 2010 · https://doi.org/10.1016/j.jaci.2010.07.019

• Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program

  American Journal of Respiratory and Critical Care Medicine · 2009 · https://doi.org/10.1164/rccm.200906-0896oc

• Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction

  European Respiratory Journal · 2008 · https://doi.org/10.1183/09031936.00018908

• Prevalence, pathogenesis, and causes of chronic cough

  The Lancet · 2008 · 10.1016/s0140-6736(08)60595-4

• Respiratory Effects of Exposure to Diesel Traffic in Persons with Asthma

  New England Journal of Medicine · 2007 · 10.1056/nejmoa071535

• ERS guidelines on the assessment of cough

  European Respiratory Journal · 2007 · 10.1183/09031936.00101006

• Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program

  Journal of Allergy and Clinical Immunology · 2007 · 10.1016/j.jaci.2006.11.639

• Efficacy and safety of a recombinant anti‐immunoglobulin E antibody (omalizumab) in severe allergic asthma

  Clinical & Experimental Allergy · 2004 · 10.1111/j.1365-2222.2004.1916.x

• Effects of Treatment with Anti-immunoglobulin E Antibody Omalizumab on Airway Inflammation in Allergic Asthma

  American Journal of Respiratory and Critical Care Medicine · 2004 · 10.1164/rccm.200312-1651oc

• Murine models of asthma

  European Respiratory Journal · 2003 · https://doi.org/10.1183/09031936.03.00026403

• Increased expression of nuclear factor-κB in bronchial biopsies from smokers and patients with COPD

  European Respiratory Journal · 2002 · https://doi.org/10.1183/09031936.02.00272002

• A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression

  Proceedings of the National Academy of Sciences · 2002 · https://doi.org/10.1073/pnas.132556899

• Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages

  The FASEB Journal · 2001 · https://doi.org/10.1096/fj.00-0432fje

• Cytokines in chronic obstructive pulmonary disease

  European Respiratory Journal · 2001 · 10.1183/09031936.01.00229701

• Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsìveness, and the late asthmatic response

  The Lancet · 2000 · 10.1016/s0140-6736(00)03496-6

• Neutrophilic Inflammation in Severe Persistent Asthma

  American Journal of Respiratory and Critical Care Medicine · 1999 · 10.1164/ajrccm.160.5.9806170

• Cytokines in asthma

  Thorax · 1999 · 10.1136/thx.54.9.825

• Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma.

  Thorax · 1998 · 10.1136/thx.53.2.91

• Inflammatory Mediators of Asthma: An Update

  Pharmacological Reviews · 1998 · 10.1016/s0031-6997(24)01381-4

• Activation and Localization of Transcription Factor, Nuclear Factor- κ B, in Asthma

  American Journal of Respiratory and Critical Care Medicine · 1998 · https://doi.org/10.1164/ajrccm.158.5.9706116

Current projects

No projects listed.