Stephen W. Fesik

Research interests

Publications

• Drugging an undruggable pocket on KRAS

  Proceedings of the National Academy of Sciences · 2019 · 10.1073/pnas.1904529116

• A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia

  Cancer Discovery · 2018 · 10.1158/2159-8290.cd-18-0140

• MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation

  Cell Metabolism · 2017 · 10.1016/j.cmet.2017.09.009

• Twenty years on: the impact of fragments on drug discovery

  Nature Reviews Drug Discovery · 2016 · 10.1038/nrd.2016.109

• Drugging the undruggable RAS: Mission Possible?

  Nature Reviews Drug Discovery · 2014 · https://doi.org/10.1038/nrd4389

• Discovery of Small Molecules that Bind to K‐Ras and Inhibit Sos‐Mediated Activation

  Angewandte Chemie International Edition · 2012 · 10.1002/anie.201201358

• ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

  Cancer Research · 2008 · https://doi.org/10.1158/0008-5472.can-07-5836

• Promoting apoptosis as a strategy for cancer drug discovery

  Nature reviews. Cancer · 2005 · 10.1038/nrc1736

• An inhibitor of Bcl-2 family proteins induces regression of solid tumours

  Nature · 2005 · https://doi.org/10.1038/nature03579

• Druggability Indices for Protein Targets Derived from NMR-Based Screening Data

  Journal of Medicinal Chemistry · 2005 · 10.1021/jm049131r

• Specificity of short interfering RNA determined through gene expression signatures

  Proceedings of the National Academy of Sciences · 2003 · 10.1073/pnas.1131959100

• Structural biology of the Bcl-2 family of proteins

  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 2003 · 10.1016/j.bbamcr.2003.08.012

• Structural Basis for the Inhibition of Caspase-3 by XIAP

  Cell · 2001 · 10.1016/s0092-8674(01)00274-4

• Solution structure of the antiapoptotic protein bcl-2

  Proceedings of the National Academy of Sciences · 2001 · 10.1073/pnas.041619798

• Rationale for Bcl‐XL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

  Protein Science · 2000 · 10.1110/ps.9.12.2528

• 14-3-3 Proteins and Survival Kinases Cooperate to Inactivate BAD by BH3 Domain Phosphorylation

  Molecular Cell · 2000 · 10.1016/s1097-2765(05)00012-2

• Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

  Nature · 2000 · 10.1038/35050006

• One-Dimensional Relaxation- and Diffusion-Edited NMR Methods for Screening Compounds That Bind to Macromolecules

  Journal of the American Chemical Society · 1997 · 10.1021/ja9715962

• Bcl-xL forms an ion channel in synthetic lipid membranes

  Nature · 1997 · https://doi.org/10.1038/385353a0

• Structure of Bcl-x L -Bak Peptide Complex: Recognition Between Regulators of Apoptosis

  Science · 1997 · https://doi.org/10.1126/science.275.5302.983

• Discovering High-Affinity Ligands for Proteins: SAR by NMR

  Science · 1996 · 10.1126/science.274.5292.1531

• NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain

  Nature · 1996 · 10.1038/384638a0

• X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

  Nature · 1996 · 10.1038/381335a0

• Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate

  Nature · 1994 · 10.1038/371168a0

• Heteronuclear three-dimensional nmr spectroscopy. A strategy for the simplification of homonuclear two-dimensional NMR spectra

  Journal of Magnetic Resonance (1969) · 1988 · 10.1016/0022-2364(88)90144-8

Current projects

No projects listed.