Jonathan A. Kropski

Research interests

Publications

• Spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis

  Nature Genetics · 2025 · 10.1038/s41588-025-02080-x

• An integrated cell atlas of the lung in health and disease

  Nature Medicine · 2023 · https://doi.org/10.1038/s41591-023-02327-2

• Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung

  Circulation · 2021 · 10.1161/circulationaha.120.052318

• A single-cell atlas of mouse lung development

  Development · 2021 · https://doi.org/10.1242/dev.199512

• Idiopathic pulmonary fibrosis: Disease mechanisms and drug development

  Pharmacology & Therapeutics · 2020 · 10.1016/j.pharmthera.2020.107798

• Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19

  Immunity · 2020 · 10.1016/j.immuni.2020.11.017

• Chronic Hypersensitivity Pneumonitis, an Interstitial Lung Disease with Distinct Molecular Signatures

  American Journal of Respiratory and Critical Care Medicine · 2020 · 10.1164/rccm.202001-0134oc

• Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis

  Nature Cell Biology · 2020 · https://doi.org/10.1038/s41556-020-0542-8

• SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.04.035

• Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis

  Science Advances · 2020 · https://doi.org/10.1126/sciadv.aba1972

• Increased monocyte count as a cellular biomarker for poor outcomes in fibrotic diseases: a retrospective, multicentre cohort study

  The Lancet Respiratory Medicine · 2019 · 10.1016/s2213-2600(18)30508-3

• Analysis of protein-altering variants in telomerase genes and their association with MUC5B common variant status in patients with idiopathic pulmonary fibrosis: a candidate gene sequencing study

  The Lancet Respiratory Medicine · 2018 · 10.1016/s2213-2600(18)30135-8

• Endoplasmic reticulum stress in the pathogenesis of fibrotic disease

  Journal of Clinical Investigation · 2018 · 10.1172/jci93560

• Idiopathic pulmonary fibrosis: Epithelial-mesenchymal interactions and emerging therapeutic targets

  Matrix Biology · 2018 · 10.1016/j.matbio.2018.03.021

• PD-1 up-regulation on CD4 + T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production

  Science Translational Medicine · 2018 · 10.1126/scitranslmed.aar8356

• The genetic basis of idiopathic pulmonary fibrosis

  European Respiratory Journal · 2015 · 10.1183/09031936.00163814

• Rare Variants in RTEL1 Are Associated with Familial Interstitial Pneumonia

  American Journal of Respiratory and Critical Care Medicine · 2015 · 10.1164/rccm.201408-1510oc

• A Novel Dyskerin (DKC1) Mutation Is Associated With Familial Interstitial Pneumonia

  CHEST Journal · 2014 · 10.1378/chest.13-2224

• Extensive Phenotyping of Individuals at Risk for Familial Interstitial Pneumonia Reveals Clues to the Pathogenesis of Interstitial Lung Disease

  American Journal of Respiratory and Critical Care Medicine · 2014 · 10.1164/rccm.201406-1162oc

• Bronchoscopic Cryobiopsy for the Diagnosis of Diffuse Parenchymal Lung Disease

  PLoS ONE · 2013 · 10.1371/journal.pone.0078674

• Genetic studies provide clues on the pathogenesis of idiopathic pulmonary fibrosis

  Disease Models & Mechanisms · 2012 · 10.1242/dmm.010736

• Clara Cell Protein (CC16), a Marker of Lung Epithelial Injury, Is Decreased in Plasma and Pulmonary Edema Fluid From Patients With Acute Lung Injury

  CHEST Journal · 2009 · 10.1378/chest.08-2465

• Procoagulant alveolar microparticles in the lungs of patients with acute respiratory distress syndrome

  American Journal of Physiology-Lung Cellular and Molecular Physiology · 2009 · 10.1152/ajplung.00214.2009

• School‐based Obesity Prevention Programs: An Evidence‐based Review

  Obesity · 2008 · 10.1038/oby.2008.29

Current projects

No projects listed.