Jashvant D. Unadkat

Research interests

Publications

• Applications, Challenges, and Outlook for PBPK Modeling and Simulation: A Regulatory, Industrial and Academic Perspective

  Pharmaceutical Research · 2022 · 10.1007/s11095-022-03274-2

• Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance

  Clinical Pharmacology & Therapeutics · 2018 · https://doi.org/10.1002/cpt.1112

• Abundance of Drug Transporters in the Human Kidney Cortex as Quantified by Quantitative Targeted Proteomics

  Drug Metabolism and Disposition · 2016 · 10.1124/dmd.116.072066

• Ontogeny of Hepatic Drug Transporters as Quantified by LC‐MS/MS Proteomics

  Clinical Pharmacology & Therapeutics · 2016 · 10.1002/cpt.409

• Protein Abundance of Clinically Relevant Multidrug Transporters along the Entire Length of the Human Intestine

  Molecular Pharmaceutics · 2014 · https://doi.org/10.1021/mp500330y

• Activity of P-Glycoprotein, a β-Amyloid Transporter at the Blood–Brain Barrier, Is Compromised in Patients with Mild Alzheimer Disease

  Journal of Nuclear Medicine · 2014 · https://doi.org/10.2967/jnumed.113.130161

• Role of the Breast Cancer Resistance Protein (BCRP/ABCG2) in Drug Transport—an Update

  The AAPS Journal · 2014 · https://doi.org/10.1208/s12248-014-9668-6

• Interspecies Variability in Expression of Hepatobiliary Transporters across Human, Dog, Monkey, and Rat as Determined by Quantitative Proteomics

  Drug Metabolism and Disposition · 2014 · https://doi.org/10.1124/dmd.114.061580

• Interindividual Variability in Hepatic Organic Anion-Transporting Polypeptides and P-Glycoprotein (ABCB1) Protein Expression: Quantification by Liquid Chromatography Tandem Mass Spectroscopy and Influence of Genotype, Age, and Sex

  Drug Metabolism and Disposition · 2013 · https://doi.org/10.1124/dmd.113.053819

• Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3

  American Journal of Physiology-Gastrointestinal and Liver Physiology · 2009 · 10.1152/ajpgi.90672.2008

• Are We Optimizing Gestational Diabetes Treatment With Glyburide? The Pharmacologic Basis for Better Clinical Practice

  Clinical Pharmacology & Therapeutics · 2009 · https://doi.org/10.1038/clpt.2009.5

• Drug interactions at the blood-brain barrier: Fact or fantasy?☆

  Pharmacology & Therapeutics · 2009 · https://doi.org/10.1016/j.pharmthera.2009.03.017

• Effects of Pregnancy on CYP3A and P-glycoprotein Activities as Measured by Disposition of Midazolam and Digoxin: A University of Washington Specialized Center of Research Study

  Clinical Pharmacology & Therapeutics · 2008 · https://doi.org/10.1038/clpt.2008.1

• In situ hybridization and immunolocalization of concentrative and equilibrative nucleoside transporters in the human intestine, liver, kidneys, and placenta

  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 2007 · 10.1152/ajpregu.00293.2007

• Cytochrome P450 Enzymes and Transporters Induced by Anti-Human Immunodeficiency Virus Protease Inhibitors in Human Hepatocytes: Implications for Predicting Clinical Drug Interactions

  Drug Metabolism and Disposition · 2007 · 10.1124/dmd.107.016089

• The role of transporters in drug interactions

  European Journal of Pharmaceutical Sciences · 2005 · https://doi.org/10.1016/j.ejps.2005.11.002

• Regulation of BCRP/ABCG2 expression by progesterone and 17β-estradiol in human placental BeWo cells

  American Journal of Physiology-Endocrinology and Metabolism · 2005 · 10.1152/ajpendo.00397.2005

• P-glycoprotein and breast cancer resistance protein expression in human placentae of various gestational ages

  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 2005 · https://doi.org/10.1152/ajpregu.00173.2005

• Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography

  Clinical Pharmacology & Therapeutics · 2005 · 10.1016/j.clpt.2005.01.022

• Mitochondrial Expression of the Human Equilibrative Nucleoside Transporter 1 (hENT1) Results in Enhanced Mitochondrial Toxicity of Antiviral Drugs

  Journal of Biological Chemistry · 2004 · 10.1074/jbc.m307938200

• HIV Protease Inhibitors Are Inhibitors but Not Substrates of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)

  Journal of Pharmacology and Experimental Therapeutics · 2004 · https://doi.org/10.1124/jpet.104.065342

• Expression of arylamine N -acetyltransferase in human intestine

  Gut · 1998 · 10.1136/gut.42.3.402

• Evaluation of the selectivity of In vitro probes and suitability of organic solvents for the measurement of human cytochrome P450 monooxygenase activities.

  PubMed · 1998

Current projects

No projects listed.