Wolf‐Dietrich Hardt

Research interests

Publications

• Definitions and guidelines for research on antibiotic persistence

  Nature Reviews Microbiology · 2019 · https://doi.org/10.1038/s41579-019-0196-3

• Multi-omic measurements of heterogeneity in HeLa cells across laboratories

  Nature Biotechnology · 2019 · 10.1038/s41587-019-0037-y

• Salmonella persisters promote the spread of antibiotic resistance plasmids in the gut

  Nature · 2019 · 10.1038/s41586-019-1521-8

• Pathogen-Induced TLR4-TRIF Innate Immune Signaling in Hematopoietic Stem Cells Promotes Proliferation but Reduces Competitive Fitness

  Cell stem cell · 2017 · 10.1016/j.stem.2017.06.013

• High-avidity IgA protects the intestine by enchaining growing bacteria

  Nature · 2017 · 10.1038/nature22058

• Epithelium-Intrinsic NAIP/NLRC4 Inflammasome Drives Infected Enterocyte Expulsion to Restrict Salmonella Replication in the Intestinal Mucosa

  Cell Host & Microbe · 2014 · 10.1016/j.chom.2014.07.001

• Stabilization of cooperative virulence by the expression of an avirulent phenotype

  Nature · 2013 · 10.1038/nature11913

• 'Blooming' in the gut: how dysbiosis might contribute to pathogen evolution

  Nature Reviews Microbiology · 2013 · 10.1038/nrmicro2989

• Gut inflammation can boost horizontal gene transfer between pathogenic and commensal Enterobacteriaceae

  Proceedings of the National Academy of Sciences · 2012 · 10.1073/pnas.1113246109

• The Cost of Virulence: Retarded Growth of Salmonella Typhimurium Cells Expressing Type III Secretion System 1

  PLoS Pathogens · 2011 · 10.1371/journal.ppat.1002143

• Like Will to Like: Abundances of Closely Related Species Can Predict Susceptibility to Intestinal Colonization by Pathogenic and Commensal Bacteria

  PLoS Pathogens · 2010 · 10.1371/journal.ppat.1000711

• The Microbiota Mediates Pathogen Clearance from the Gut Lumen after Non-Typhoidal Salmonella Diarrhea

  PLoS Pathogens · 2010 · 10.1371/journal.ppat.1001097

• Mechanisms controlling pathogen colonization of the gut

  Current Opinion in Microbiology · 2010 · 10.1016/j.mib.2010.10.003

• Intestinal Lamina Propria Dendritic Cell Subsets Have Different Origin and Functions

  Immunity · 2009 · https://doi.org/10.1016/j.immuni.2009.06.025

• Clostridium difficile Toxin CDT Induces Formation of Microtubule-Based Protrusions and Increases Adherence of Bacteria

  PLoS Pathogens · 2009 · 10.1371/journal.ppat.1000626

• Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism

  Science · 2009 · https://doi.org/10.1126/science.1172747

• The role of microbiota in infectious disease

  Trends in Microbiology · 2008 · 10.1016/j.tim.2007.12.008

• Self-destructive cooperation mediated by phenotypic noise

  Nature · 2008 · 10.1038/nature07067

• Salmonella enterica Serovar Typhimurium Exploits Inflammation to Compete with the Intestinal Microbiota

  PLoS Biology · 2007 · https://doi.org/10.1371/journal.pbio.0050244

• The Salmonella Pathogenicity Island (SPI)-2 and SPI-1 Type III Secretion Systems Allow Salmonella Serovar typhimurium to Trigger Colitis via MyD88-Dependent and MyD88-Independent Mechanisms

  The Journal of Immunology · 2005 · 10.4049/jimmunol.174.3.1675

• Flagella and Chemotaxis Are Required for Efficient Induction ofSalmonella entericaSerovar Typhimurium Colitis in Streptomycin-Pretreated Mice

  Infection and Immunity · 2004 · 10.1128/iai.72.7.4138-4150.2004

• Phages and the Evolution of Bacterial Pathogens: from Genomic Rearrangements to Lysogenic Conversion

  Microbiology and Molecular Biology Reviews · 2004 · https://doi.org/10.1128/mmbr.68.3.560-602.2004

• Pretreatment of Mice with Streptomycin Provides a Salmonella enterica Serovar Typhimurium Colitis Model That Allows Analysis of Both Pathogen and Host

  Infection and Immunity · 2003 · 10.1128/iai.71.5.2839-2858.2003

• Identification of SopE2 from Salmonella typhimurium , a conserved guanine nucleotide exchange factor for Cdc42 of the host cell

  Molecular Microbiology · 2000 · 10.1046/j.1365-2958.2000.01933.x

• S. typhimurium Encodes an Activator of Rho GTPases that Induces Membrane Ruffling and Nuclear Responses in Host Cells

  Cell · 1998 · 10.1016/s0092-8674(00)81442-7

Current projects

No projects listed.