Adriano Aguzzi

Research interests

Publications

• Microglia states and nomenclature: A field at its crossroads

  Neuron · 2022 · https://doi.org/10.1016/j.neuron.2022.10.020

• The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

  Nature Immunology · 2014 · https://doi.org/10.1038/ni.2913

• Microglia: Scapegoat, Saboteur, or Something Else?

  Science · 2013 · 10.1126/science.1227901

• Protein aggregation diseases: pathogenicity and therapeutic perspectives

  Nature Reviews Drug Discovery · 2010 · 10.1038/nrd3050

• An Analytical Solution to the Kinetics of Breakable Filament Assembly

  Science · 2009 · https://doi.org/10.1126/science.1178250

• The Transcellular Spread of Cytosolic Amyloids, Prions, and Prionoids

  Neuron · 2009 · 10.1016/j.neuron.2009.12.016

• Prions: Protein Aggregation and Infectious Diseases

  Physiological Reviews · 2009 · 10.1152/physrev.00006.2009

• Genetic prion disease: the EUROCJD experience

  Human Genetics · 2005 · 10.1007/s00439-005-0020-1

• Experimental autoimmune encephalomyelitis repressed by microglial paralysis

  Nature Medicine · 2005 · https://doi.org/10.1038/nm1177

• The AP-1 Transcription Factor c-Jun Is Required for Efficient Axonal Regeneration

  Neuron · 2004 · 10.1016/j.neuron.2004.06.005

• Mammalian Prion Biology

  Cell · 2004 · 10.1016/s0092-8674(03)01031-6

• Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration

  Nature Medicine · 2004 · 10.1038/nm987

• p62 Is a Common Component of Cytoplasmic Inclusions in Protein Aggregation Diseases

  American Journal Of Pathology · 2002 · 10.1016/s0002-9440(10)64369-6

• Mice with Combined Gene Knock-Outs Reveal Essential and Partially Redundant Functions of Amyloid Precursor Protein Family Members

  Journal of Neuroscience · 2000 · 10.1523/jneurosci.20-21-07951.2000

• The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice

  Nature Genetics · 1999 · 10.1038/10338

• Expression of Amino-Terminally Truncated PrP in the Mouse Leading to Ataxia and Specific Cerebellar Lesions

  Cell · 1998 · 10.1016/s0092-8674(00)81572-x

• A crucial role for B cells in neuroinvasive scrapie

  Nature · 1997 · 10.1038/37789

• Normal host prion protein necessary for scrapie-induced neurotoxicity

  Nature · 1996 · 10.1038/379339a0

• Prion protein (PrP) with amino‐proximal deletions restoring susceptibility of PrP knockout mice to scrapie.

  The EMBO Journal · 1996 · 10.1002/j.1460-2075.1996.tb00467.x

• Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

  Nature · 1995 · https://doi.org/10.1038/376768a0

• Deficient signaling in mice devoid of double‐stranded RNA‐dependent protein kinase.

  The EMBO Journal · 1995 · 10.1002/j.1460-2075.1995.tb00300.x

• Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation.

  Genes & Development · 1995 · https://doi.org/10.1101/gad.9.13.1608

• c-Jun is essential for normal mouse development and hepatogenesis

  Nature · 1993 · 10.1038/365179a0

• Mice devoid of PrP are resistant to scrapie

  Cell · 1993 · https://doi.org/10.1016/0092-8674(93)90360-3

• Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis.

  Genes & Development · 1992 · 10.1101/gad.6.9.1589

Current projects

No projects listed.