Colm Cunningham

Research interests

Publications

• Neuroinflammation in Alzheimer disease

  Nature reviews. Immunology · 2024 · https://doi.org/10.1038/s41577-024-01104-7

• Update of the European Society of Anaesthesiology and Intensive Care Medicine evidence-based and consensus-based guideline on postoperative delirium in adult patients

  European Journal of Anaesthesiology · 2023 · 10.1097/eja.0000000000001876

• Microglia states and nomenclature: A field at its crossroads

  Neuron · 2022 · https://doi.org/10.1016/j.neuron.2022.10.020

• Reactive astrocyte nomenclature, definitions, and future directions

  Nature Neuroscience · 2021 · https://doi.org/10.1038/s41593-020-00783-4

• Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL‐1β drives amplified responses in primed astrocytes and neuronal network dysfunction

  Alzheimer s & Dementia · 2021 · 10.1002/alz.12341

• Delirium

  Nature Reviews Disease Primers · 2020 · https://doi.org/10.1038/s41572-020-00223-4

• Priming Microglia for Innate Immune Memory in the Brain

  Trends in Immunology · 2019 · 10.1016/j.it.2019.02.001

• Association of Delirium With Cognitive Decline in Late Life

  JAMA Psychiatry · 2017 · 10.1001/jamapsychiatry.2016.3423

• The intensive care delirium research agenda: a multinational, interprofessional perspective

  Intensive Care Medicine · 2017 · 10.1007/s00134-017-4860-7

• The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

  Immunity · 2016 · 10.1016/j.immuni.2016.02.004

• A Systematic Analysis of the Peripheral and CNS Effects of Systemic LPS, IL-1Β, TNF-α and IL-6 Challenges in C57BL/6 Mice

  PLoS ONE · 2013 · 10.1371/journal.pone.0069123

• Delirium is a strong risk factor for dementia in the oldest-old: a population-based cohort study

  Brain · 2012 · 10.1093/brain/aws190

• Microglia and neurodegeneration: The role of systemic inflammation

  Glia · 2012 · 10.1002/glia.22350

• Proinflammatory cytokines, sickness behavior, and Alzheimer disease

  Neurology · 2011 · 10.1212/wnl.0b013e318225ae07

• Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium

  Neurobiology of Aging · 2010 · 10.1016/j.neurobiolaging.2010.04.002

• Systemic inflammation and disease progression in Alzheimer disease

  Neurology · 2009 · https://doi.org/10.1212/wnl.0b013e3181b6bb95

• Systemic Inflammation Induces Acute Behavioral and Cognitive Changes and Accelerates Neurodegenerative Disease

  Biological Psychiatry · 2008 · 10.1016/j.biopsych.2008.07.024

• Unravelling the pathophysiology of delirium: A focus on the role of aberrant stress responses

  Journal of Psychosomatic Research · 2008 · 10.1016/j.jpsychores.2008.05.019

• The sickness behaviour and CNS inflammatory mediator profile induced by systemic challenge of mice with synthetic double-stranded RNA (poly I:C)

  Brain Behavior and Immunity · 2007 · 10.1016/j.bbi.2006.12.007

• Systemic infections and inflammation affect chronic neurodegeneration

  Nature reviews. Immunology · 2007 · 10.1038/nri2015

• Adaptive Responses by Mouse Early Embryos to Maternal Diet Protect Fetal Growth but Predispose to Adult Onset Disease1

  Biology of Reproduction · 2007 · 10.1095/biolreprod.107.064220

• Central and Systemic Endotoxin Challenges Exacerbate the Local Inflammatory Response and Increase Neuronal Death during Chronic Neurodegeneration

  Journal of Neuroscience · 2005 · 10.1523/jneurosci.2614-05.2005

• The impact of systemic infection on the progression of neurodegenerative disease

  Nature reviews. Neuroscience · 2003 · 10.1038/nrn1032

• Synaptic changes characterize early behavioural signs in the ME7 model of murine prion disease

  European Journal of Neuroscience · 2003 · 10.1046/j.1460-9568.2003.02662.x

• Peripheral infection evokes exaggerated sickness behaviour in pre-clinical murine prion disease

  Neuroscience · 2002 · 10.1016/s0306-4522(02)00030-1

Current projects

No projects listed.