Martin McMahon

Research interests

Publications

• Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers

  Nature Medicine · 2019 · 10.1038/s41591-019-0367-9

• The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

  Nature Genetics · 2015 · 10.1038/ng.3218

• Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond

  Nature reviews. Cancer · 2014 · https://doi.org/10.1038/nrc3760

• Response to BRAF Inhibition in Melanoma Is Enhanced When Combined with Immune Checkpoint Blockade

  Cancer Immunology Research · 2014 · https://doi.org/10.1158/2326-6066.cir-13-0215

• Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of Braf V600E–Driven Lung Tumors

  Cancer Discovery · 2013 · 10.1158/2159-8290.cd-13-0397

• Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance

  Nature · 2013 · 10.1038/nature11814

• Elucidating Distinct Roles for NF1 in Melanomagenesis

  Cancer Discovery · 2012 · https://doi.org/10.1158/2159-8290.cd-12-0313

• A Central Role for RAF→MEK→ERK Signaling in the Genesis of Pancreatic Ductal Adenocarcinoma

  Cancer Discovery · 2012 · 10.1158/2159-8290.cd-11-0347

• Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis

  Genes & Development · 2012 · 10.1101/gad.187252.112

• An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background

  Nature · 2012 · 10.1038/nature11624

• β-Catenin Signaling Controls Metastasis in Braf-Activated Pten-Deficient Melanomas

  Cancer Cell · 2011 · 10.1016/j.ccr.2011.10.030

• BrafV600E cooperates with Pten loss to induce metastatic melanoma

  Nature Genetics · 2009 · https://doi.org/10.1038/ng.356

• A new mouse model to explore the initiation, progression, and therapy of BRAF V600E -induced lung tumors

  Genes & Development · 2007 · 10.1101/gad.1516407

• Constitutive Activation of Akt by Flt3 Internal Tandem Duplications Is Necessary for Increased Survival, Proliferation, and Myeloid Transformation

  Cancer Research · 2005 · 10.1158/0008-5472.can-05-0422

• Pharmacologic Inhibition of RAF→MEK→ERK Signaling Elicits Pancreatic Cancer Cell Cycle Arrest Through Induced Expression of p27Kip1

  Cancer Research · 2005 · https://doi.org/10.1158/0008-5472.can-04-2848

• Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

  Nature · 2003 · https://doi.org/10.1038/nature02009

• Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma.

  PubMed · 2001

• Analysis of the transcriptional program induced by Raf in epithelial cells

  Genes & Development · 2001 · 10.1101/gad.191101

• Raf induces TGFβ production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells

  Genes & Development · 2000 · 10.1101/gad.181700

• Opposing Effects of Ras on p53

  Cell · 2000 · 10.1016/s0092-8674(00)00123-9

• Identification and Characterization of a Constitutively Active STAT5 Mutant That Promotes Cell Proliferation

  Molecular and Cellular Biology · 1998 · 10.1128/mcb.18.7.3871

• Senescence of human fibroblasts induced by oncogenic Raf

  Genes & Development · 1998 · https://doi.org/10.1101/gad.12.19.2997

• Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21Cip1

  Molecular and Cellular Biology · 1997 · 10.1128/mcb.17.9.5598

• Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

  Science · 1994 · https://doi.org/10.1126/science.7992057

• Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase.

  Molecular and Cellular Biology · 1993 · 10.1128/mcb.13.10.6241

• Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells

  Cell · 1984 · 10.1016/0092-8674(84)90270-8

Current projects

No projects listed.