John C. Morris

Research interests

Publications

• APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

  Nature · 2020 · https://doi.org/10.1038/s41586-020-2247-3

• A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease

  Nature Medicine · 2020 · https://doi.org/10.1038/s41591-020-0781-z

• Efficacy of Selpercatinib in RET -Altered Thyroid Cancers

  New England Journal of Medicine · 2020 · https://doi.org/10.1056/nejmoa2005651

• Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-020-15701-2

• Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease

  Nature Medicine · 2019 · 10.1038/s41591-018-0304-3

• Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

  Nature Medicine · 2019 · https://doi.org/10.1038/s41591-018-0297-y

• Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

  Nature Communications · 2018 · 10.1038/s41467-018-05892-0

• Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study

  The Lancet Neurology · 2018 · 10.1016/s1474-4422(18)30028-0

• ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

  Nature · 2017 · 10.1038/nature24016

• Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

  Nature Communications · 2016 · 10.1038/ncomms11934

• Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia

  JAMA · 2015 · 10.1001/jama.2015.4668

• The Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception

  Alzheimer s & Dementia · 2013 · 10.1016/j.jalz.2013.05.1769

• Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

  New England Journal of Medicine · 2012 · https://doi.org/10.1056/nejmoa1202753

• Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

  Journal of Neuropathology & Experimental Neurology · 2012 · 10.1097/nen.0b013e31825018f7

• Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

  Nature Genetics · 2011 · 10.1038/ng.803

• The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

  Alzheimer s & Dementia · 2011 · https://doi.org/10.1016/j.jalz.2011.03.005

• Alzheimer’s Disease: The Challenge of the Second Century

  Science Translational Medicine · 2011 · 10.1126/scitranslmed.3002369

• Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

  Nature Genetics · 2010 · 10.1038/ng.536

• Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease

  Science · 2010 · 10.1126/science.1197623

• Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease

  PLoS ONE · 2010 · 10.1371/journal.pone.0013950

• Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

  Nature Genetics · 2009 · 10.1038/ng.440

• Open Access Series of Imaging Studies (OASIS): Cross-sectional MRI Data in Young, Middle Aged, Nondemented, and Demented Older Adults

  Journal of Cognitive Neuroscience · 2007 · 10.1162/jocn.2007.19.9.1498

• Molecular, Structural, and Functional Characterization of Alzheimer's Disease: Evidence for a Relationship between Default Activity, Amyloid, and Memory

  Journal of Neuroscience · 2005 · 10.1523/jneurosci.2177-05.2005

• A unified approach for morphometric and functional data analysis in young, old, and demented adults using automated atlas-based head size normalization: reliability and validation against manual measurement of total intracranial volume

  NeuroImage · 2004 · 10.1016/j.neuroimage.2004.06.018

• Current Concepts in Mild Cognitive Impairment

  Archives of Neurology · 2001 · https://doi.org/10.1001/archneur.58.12.1985

• Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

  Nature · 1998 · 10.1038/31508

• Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease

  Journal of Neuroscience · 1996 · 10.1523/jneurosci.16-14-04491.1996

• The Clinical Dementia Rating (CDR)

  Neurology · 1993 · https://doi.org/10.1212/wnl.43.11.2412-a

• Kinetics of Adsorption on Carbon from Solution

  Journal of the Sanitary Engineering Division · 1963 · https://doi.org/10.1061/jsedai.0000430

Current projects

No projects listed.