Themistocles L. Assimes

Research interests

Publications

• Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program

  Science · 2024 · 10.1126/science.adj1182

• Large-scale genome-wide association study of coronary artery disease in genetically diverse populations

  Nature Medicine · 2022 · 10.1038/s41591-022-01891-3

• Genetics of 35 blood and urine biomarkers in the UK Biobank

  Nature Genetics · 2021 · 10.1038/s41588-020-00757-z

• Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-020-0637-y

• DNA methylation GrimAge strongly predicts lifespan and healthspan

  Aging · 2019 · https://doi.org/10.18632/aging.101684

• DNA methylation-based estimator of telomere length

  Aging · 2019 · 10.18632/aging.102173

• An epigenetic biomarker of aging for lifespan and healthspan

  Aging · 2018 · https://doi.org/10.18632/aging.101414

• Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program

  Nature Genetics · 2018 · https://doi.org/10.1038/s41588-018-0222-9

• Genetic evidence of assortative mating in humans

  Nature Human Behaviour · 2017 · 10.1038/s41562-016-0016

• Epigenetic clock analysis of diet, exercise, education, and lifestyle factors

  Aging · 2017 · https://doi.org/10.18632/aging.101168

• Association analyses based on false discovery rate implicate new loci for coronary artery disease

  Nature Genetics · 2017 · 10.1038/ng.3913

• Exome-wide association study of plasma lipids in >300,000 individuals

  Nature Genetics · 2017 · 10.1038/ng.3977

• Menopause accelerates biological aging

  Proceedings of the National Academy of Sciences · 2016 · 10.1073/pnas.1604558113

• DNA methylation-based measures of biological age: meta-analysis predicting time to death

  Aging · 2016 · 10.18632/aging.101020

• The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

  The Journal of Experimental Medicine · 2016 · 10.1084/jem.20150900

• An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease

  Genome biology · 2016 · 10.1186/s13059-016-1030-0

• A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

  Nature Genetics · 2015 · 10.1038/ng.3396

• Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction

  Nature · 2014 · 10.1038/nature13917

• Clinical Interpretation and Implications of Whole-Genome Sequencing

  JAMA · 2014 · 10.1001/jama.2014.1717

• Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity

  Diabetes · 2013 · 10.2337/db13-0949

• Large-scale association analysis identifies new risk loci for coronary artery disease

  Nature Genetics · 2012 · 10.1038/ng.2480

• FTO genotype is associated with phenotypic variability of body mass index

  Nature · 2012 · 10.1038/nature11401

• Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

  Nature Genetics · 2011 · 10.1038/ng.784

• Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies

  The Lancet · 2011 · 10.1016/s0140-6736(10)61996-4

• Genome-wide meta-analyses identify multiple loci associated with smoking behavior

  Nature Genetics · 2010 · 10.1038/ng.571

Current projects

No projects listed.