Marina A. Lynch

Research interests

Publications

• Microglia states and nomenclature: A field at its crossroads

  Neuron · 2022 · https://doi.org/10.1016/j.neuron.2022.10.020

• Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease

  Communications Biology · 2021 · 10.1038/s42003-021-02259-y

• Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice

  Brain Pathology · 2019 · 10.1111/bpa.12704

• Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice

  Brain Behavior and Immunity · 2017 · https://doi.org/10.1016/j.bbi.2017.10.017

• Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice

  Brain Behavior and Immunity · 2016 · https://doi.org/10.1016/j.bbi.2016.12.014

• Modulation of Intestinal Microbiota by the Probiotic VSL#3 Resets Brain Gene Expression and Ameliorates the Age-Related Deficit in LTP

  PLoS ONE · 2014 · 10.1371/journal.pone.0106503

• IFN-γ Production by Amyloid β–Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer’s Disease

  The Journal of Immunology · 2013 · 10.4049/jimmunol.1200947

• Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction

  Journal of Neurochemistry · 2011 · 10.1111/j.1471-4159.2011.07178.x

• Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis

  Brain Behavior and Immunity · 2010 · 10.1016/j.bbi.2010.01.014

• The Multifaceted Profile of Activated Microglia

  Molecular Neurobiology · 2009 · 10.1007/s12035-009-8077-9

• Fractalkine‐induced activation of the phosphatidylinositol‐3 kinase pathway attentuates microglial activation in vivo and in vitro

  Journal of Neurochemistry · 2009 · 10.1111/j.1471-4159.2009.06253.x

• CD200 Ligand–Receptor Interaction Modulates Microglial ActivationIn VivoandIn Vitro: A Role for IL-4

  Journal of Neuroscience · 2007 · 10.1523/jneurosci.1781-07.2007

• The age‐related attenuation in long‐term potentiation is associated with microglial activation

  Journal of Neurochemistry · 2006 · 10.1111/j.1471-4159.2006.04165.x

• Long-Term Potentiation and Memory

  Physiological Reviews · 2004 · https://doi.org/10.1152/physrev.00014.2003

• Role of Interleukin-4 in Regulation of Age-related Inflammatory Changes in the Hippocampus

  Journal of Biological Chemistry · 2004 · 10.1074/jbc.m412170200

• Activation of p38 Plays a Pivotal Role in the Inhibitory Effect of Lipopolysaccharide and Interleukin-1β on Long Term Potentiation in Rat Dentate Gyrus

  Journal of Biological Chemistry · 2003 · 10.1074/jbc.m301938200

• Lipopolysaccharide Inhibits Long Term Potentiation in the Rat Dentate Gyrus by Activating Caspase-1

  Journal of Biological Chemistry · 2000 · 10.1074/jbc.m002226200

• The Inhibitory Effect of Interleukin-1β on Long-Term Potentiation Is Coupled with Increased Activity of Stress-Activated Protein Kinases

  Journal of Neuroscience · 2000 · 10.1523/jneurosci.20-18-06811.2000

• Age-related changes in synaptic function: analysis of the effect of dietary supplementation with ω-3 fatty acids

  Neuroscience · 1999 · 10.1016/s0306-4522(99)00219-5

• Evidence That Increased Hippocampal Expression of the Cytokine Interleukin-1β Is a Common Trigger for Age- and Stress-Induced Impairments in Long-Term Potentiation

  Journal of Neuroscience · 1998 · 10.1523/jneurosci.18-08-02974.1998

• Evidence that increased hippocampal expression of the cytokine interleukin-1 beta is a common trigger for age- and stress-induced impairments in long-term potentiation.

  PubMed · 1998 · 10.1523/jneurosci.18-08-02974.1998

• Interleukin-1β (IL-1β) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro

  Neuroscience Letters · 1996 · 10.1016/0304-3940(95)12252-4

• Arachidonic acid induces a long-term activity-dependent enhancement of synaptic transmission in the hippocampus

  Nature · 1989 · https://doi.org/10.1038/341739a0

• Long-term potentiation in the dentate gyrus: induction and increased glutamate release are blocked by d(−)aminophosphonovalerate

  Neuroscience · 1987 · 10.1016/0306-4522(87)90019-4

• Correlation between long‐term potentiation and release of endogenous amino acids from dentate gyrus of anaesthetized rats.

  The Journal of Physiology · 1986 · 10.1113/jphysiol.1986.sp016193

Current projects

No projects listed.