Luke O'neill

Research interests

Publications

• Trained immunity, tolerance, priming and differentiation: distinct immunological processes

  Nature Immunology · 2020 · https://doi.org/10.1038/s41590-020-00845-6

• Itaconate: the poster child of metabolic reprogramming in macrophage function

  Nature reviews. Immunology · 2019 · https://doi.org/10.1038/s41577-019-0128-5

• Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

  Science Translational Medicine · 2018 · 10.1126/scitranslmed.aah4066

• Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

  Nature · 2018 · https://doi.org/10.1038/nature25986

• A guiding map for inflammation

  Nature Immunology · 2017 · https://doi.org/10.1038/ni.3790

• Macrophage Immunometabolism: Where Are We (Going)?

  Trends in Immunology · 2017 · 10.1016/j.it.2017.03.001

• Mitochondria are the powerhouses of immunity

  Nature Immunology · 2017 · 10.1038/ni.3704

• Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

  Cell · 2016 · https://doi.org/10.1016/j.cell.2016.08.064

• Trained immunity: A program of innate immune memory in health and disease

  Science · 2016 · https://doi.org/10.1126/science.aaf1098

• A guide to immunometabolism for immunologists

  Nature reviews. Immunology · 2016 · https://doi.org/10.1038/nri.2016.70

• Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

  Cell Metabolism · 2016 · 10.1016/j.cmet.2016.10.008

• Immunometabolism governs dendritic cell and macrophage function

  The Journal of Experimental Medicine · 2015 · 10.1084/jem.20151570

• Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

  Cell Metabolism · 2015 · 10.1016/j.cmet.2014.12.005

• A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

  Nature Medicine · 2015 · https://doi.org/10.1038/nm.3806

• Metabolic reprogramming in macrophages and dendritic cells in innate immunity

  Cell Research · 2015 · 10.1038/cr.2015.68

• mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

  Science · 2014 · 10.1126/science.1250684

• The history of Toll-like receptors — redefining innate immunity

  Nature reviews. Immunology · 2013 · 10.1038/nri3446

• Succinate is an inflammatory signal that induces IL-1β through HIF-1α

  Nature · 2013 · https://doi.org/10.1038/nature11986

• Metabolism of inflammation limited by AMPK and pseudo-starvation

  Nature · 2013 · 10.1038/nature11862

• A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes

  Science · 2013 · 10.1126/science.1240925

• Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

  Nature Immunology · 2010 · 10.1038/ni.1935

• Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21

  Nature Immunology · 2009 · 10.1038/ni.1828

• The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

  Nature reviews. Immunology · 2007 · https://doi.org/10.1038/nri2079

• Resolution of in flammation: state of the art, definitions and terms

  The FASEB Journal · 2007 · 10.1096/fj.06-7227rev

• Negative regulation of Toll-like receptor-mediated immune responses

  Nature reviews. Immunology · 2005 · 10.1038/nri1630

• Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4

  Immunology · 2004 · 10.1111/j.1365-2567.2004.01976.x

• Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

  Nature · 2001 · 10.1038/35092578

• NF-kB: a crucial transcription factor for glial and neuronal cell function

  Trends in Neurosciences · 1997 · 10.1016/s0166-2236(96)01035-1

Current projects

No projects listed.