Hilal A. Lashuel

Research interests

Publications

• Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease

  npj Parkinson s Disease · 2021 · https://doi.org/10.1038/s41531-021-00203-9

• The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

  Proceedings of the National Academy of Sciences · 2020 · https://doi.org/10.1073/pnas.1913904117

• Half a century of amyloids: past, present and future

  Chemical Society Reviews · 2020 · https://doi.org/10.1039/c9cs00199a

• The many faces of α-synuclein: from structure and toxicity to therapeutic target

  Nature reviews. Neuroscience · 2012 · https://doi.org/10.1038/nrn3406

• α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, and Escherichia coli Exists Predominantly as Disordered Monomer

  Journal of Biological Chemistry · 2012 · https://doi.org/10.1074/jbc.m111.318949

• Amyloid pores from pathogenic mutations

  Nature · 2002 · https://doi.org/10.1038/418291a

• α-Synuclein, Especially the Parkinson's Disease-associated Mutants, Forms Pore-like Annular and Tubular Protofibrils

  Journal of Molecular Biology · 2002 · https://doi.org/10.1016/s0022-2836(02)00735-0

• The UCH-L1 Gene Encodes Two Opposing Enzymatic Activities that Affect α-Synuclein Degradation and Parkinson's Disease Susceptibility

  Cell · 2002 · https://doi.org/10.1016/s0092-8674(02)01012-7

Current projects

No projects listed.