Olivier Elemento

Research interests

Publications

• An atlas of substrate specificities for the human serine/threonine kinome

  Nature · 2023 · https://doi.org/10.1038/s41586-022-05575-3

• Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis

  Nature · 2020 · https://doi.org/10.1038/s41586-020-2712-z

• Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture

  Nature · 2020 · https://doi.org/10.1038/s41586-020-3017-y

• Deep learning enables robust assessment and selection of human blastocysts after in vitro fertilization

  npj Digital Medicine · 2019 · https://doi.org/10.1038/s41746-019-0096-y

• Clinical features of neuroendocrine prostate cancer

  European Journal of Cancer · 2019 · https://doi.org/10.1016/j.ejca.2019.08.011

• Deep learning-based classification of mesothelioma improves prediction of patient outcome

  Nature Medicine · 2019 · https://doi.org/10.1038/s41591-019-0583-3

• Patient derived organoids to model rare prostate cancer phenotypes

  Nature Communications · 2018 · https://doi.org/10.1038/s41467-018-04495-z

• The chromatin accessibility landscape of primary human cancers

  Science · 2018 · https://doi.org/10.1126/science.aav1898

• Chromosomal instability drives metastasis through a cytosolic DNA response

  Nature · 2018 · https://doi.org/10.1038/nature25432

• Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4–insufficient subjects

  Journal of Allergy and Clinical Immunology · 2018 · https://doi.org/10.1016/j.jaci.2018.02.055

• Deep Convolutional Neural Networks Enable Discrimination of Heterogeneous Digital Pathology Images

  EBioMedicine · 2017 · https://doi.org/10.1016/j.ebiom.2017.12.026

• Conversion of adult endothelium to immunocompetent haematopoietic stem cells

  Nature · 2017 · https://doi.org/10.1038/nature22326

• Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine

  Cancer Discovery · 2017 · https://doi.org/10.1158/2159-8290.cd-16-1154

• Clonal evolution of chemotherapy-resistant urothelial carcinoma

  Nature Genetics · 2016 · https://doi.org/10.1038/ng.3692

• Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer

  New England Journal of Medicine · 2016 · 10.1056/nejmoa1603144

• Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer

  Nature Medicine · 2016 · 10.1038/nm.4045

• Transcriptome Analysis of Individual Stromal Cell Populations Identifies Stroma-Tumor Crosstalk in Mouse Lung Cancer Model

  Cell Reports · 2015 · https://doi.org/10.1016/j.celrep.2015.01.040

• Integrative Clinical Genomics of Advanced Prostate Cancer

  Cell · 2015 · 10.1016/j.cell.2015.05.001

• Histone Methyltransferase MMSET/NSD2 Alters EZH2 Binding and Reprograms the Myeloma Epigenome through Global and Focal Changes in H3K36 and H3K27 Methylation

  PLoS Genetics · 2014 · https://doi.org/10.1371/journal.pgen.1004566

• Reprogramming human endothelial cells to haematopoietic cells requires vascular induction

  Nature · 2014 · https://doi.org/10.1038/nature13547

• Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony–forming cells

  Nature Biotechnology · 2014 · https://doi.org/10.1038/nbt.3048

• Punctuated Evolution of Prostate Cancer Genomes

  Cell · 2013 · 10.1016/j.cell.2013.03.021

• Molecular Signatures of Tissue-Specific Microvascular Endothelial Cell Heterogeneity in Organ Maintenance and Regeneration

  Developmental Cell · 2013 · https://doi.org/10.1016/j.devcel.2013.06.017

• EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation

  Cancer Cell · 2013 · https://doi.org/10.1016/j.ccr.2013.04.011

• Efficient Direct Reprogramming of Mature Amniotic Cells into Endothelial Cells by ETS Factors and TGFβ Suppression

  Cell · 2012 · https://doi.org/10.1016/j.cell.2012.09.032

Current projects

No projects listed.