James W. Dennis

Research interests

Publications

• A Genetic Map of the Response to DNA Damage in Human Cells

  Cell · 2020 · 10.1016/j.cell.2020.05.040

• The galectin lattice at a glance

  Journal of Cell Science · 2015 · 10.1242/jcs.151159

• Temporal regulation of EGF signalling networks by the scaffold protein Shc1

  Nature · 2013 · 10.1038/nature12308

• Glycosylation, galectins and cellular signaling

  Current Opinion in Cell Biology · 2011 · 10.1016/j.ceb.2011.05.001

• The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism

  Genes & Development · 2010 · 10.1101/gad.1985910

• Adaptive Regulation at the Cell Surface by N ‐Glycosylation

  Traffic · 2009 · 10.1111/j.1600-0854.2009.00981.x

• Lattices, rafts, and scaffolds: domain regulation of receptor signaling at the plasma membrane

  The Journal of Cell Biology · 2009 · 10.1083/jcb.200811059

• Metabolism, Cell Surface Organization, and Disease

  Cell · 2009 · 10.1016/j.cell.2009.12.008

• Complex N-Glycan Number and Degree of Branching Cooperate to Regulate Cell Proliferation and Differentiation

  Cell · 2007 · https://doi.org/10.1016/j.cell.2007.01.049

• Plasma membrane domain organization regulates EGFR signaling in tumor cells

  The Journal of Cell Biology · 2007 · 10.1083/jcb.200611106

• Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis

  Nature Genetics · 2005 · 10.1038/ng1605

• Regulation of Cytokine Receptors by Golgi N-Glycan Processing and Endocytosis

  Science · 2004 · https://doi.org/10.1126/science.1102109

• Interferon Alfacon-1 Plus Corticosteroids in Severe Acute Respiratory Syndrome

  JAMA · 2003 · 10.1001/jama.290.24.3222

• α2-HS Glycoprotein/Fetuin, a Transforming Growth Factor-β/Bone Morphogenetic Protein Antagonist, Regulates Postnatal Bone Growth and Remodeling

  Journal of Biological Chemistry · 2002 · 10.1074/jbc.m112234200

• Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation

  Nature · 2001 · https://doi.org/10.1038/35055582

• Suppression of tumor growth and metastasis in Mgat5-deficient mice

  Nature Medicine · 2000 · 10.1038/73163

• Protein glycosylation in development and disease

  BioEssays · 1999 · 10.1002/(sici)1521-1878(199905)21:5<412::aid-bies8>3.0.co;2-5

• Glycoprotein glycosylation and cancer progression

  Biochimica et Biophysica Acta (BBA) - General Subjects · 1999 · https://doi.org/10.1016/s0304-4165(99)00167-1

• Fetuin/α2-HS Glycoprotein Is a Transforming Growth Factor-β Type II Receptor Mimic and Cytokine Antagonist

  Journal of Biological Chemistry · 1996 · 10.1074/jbc.271.22.12755

• Inhibitors of carbohydrate processing: A new class of anticancer agents.

  PubMed · 1995

• Reduced contact-inhibition and substratum adhesion in epithelial cells expressing GlcNAc-transferase V.

  The Journal of Cell Biology · 1995 · 10.1083/jcb.130.2.383

• Beta 1-6 branched oligosaccharides as a marker of tumor progression in human breast and colon neoplasia.

  PubMed · 1991

• Increased UDP-GlcNAc:Gal beta 1-3GaLNAc-R (GlcNAc to GaLNAc) beta-1, 6-N-acetylglucosaminyltransferase activity in metastatic murine tumor cell lines. Control of polylactosamine synthesis

  Journal of Biological Chemistry · 1991 · 10.1016/s0021-9258(18)52362-0

• β1-6 Branching of Asn-Linked Oligosaccharides Is Directly Associated with Metastasis

  Science · 1987 · https://doi.org/10.1126/science.2953071

• Effects of swainsonine and polyinosinic:polycytidylic acid on murine tumor cell growth and metastasis.

  PubMed · 1986

Current projects

No projects listed.