Berthold Göttgens

Research interests

Publications

• Single-cell multi-omics analysis of the immune response in COVID-19

  Nature Medicine · 2021 · https://doi.org/10.1038/s41591-021-01329-2

• Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease

  Immunity · 2021 · 10.1016/j.immuni.2021.05.010

• Local and systemic responses to SARS-CoV-2 infection in children and adults

  Nature · 2021 · 10.1038/s41586-021-04345-x

• Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis

  Nature Biotechnology · 2021 · 10.1038/s41587-021-01006-2

• Decoding human fetal liver haematopoiesis

  Nature · 2019 · 10.1038/s41586-019-1652-y

• A single-cell molecular map of mouse gastrulation and early organogenesis

  Nature · 2019 · https://doi.org/10.1038/s41586-019-0933-9

• PAGA: graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells

  Genome biology · 2019 · https://doi.org/10.1186/s13059-019-1663-x

• Multi-omics profiling of mouse gastrulation at single-cell resolution

  Nature · 2019 · 10.1038/s41586-019-1825-8

• From haematopoietic stem cells to complex differentiation landscapes

  Nature · 2018 · 10.1038/nature25022

• Establishment of mouse expanded potential stem cells

  Nature · 2017 · 10.1038/nature24052

• Resolving early mesoderm diversification through single-cell expression profiling

  Nature · 2016 · 10.1038/nature18633

• A single-cell resolution map of mouse hematopoietic stem and progenitor cell differentiation

  Blood · 2016 · 10.1182/blood-2016-05-716480

• Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells

  Science · 2015 · 10.1126/science.aaa7227

• Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations

  Cell stem cell · 2015 · 10.1016/j.stem.2015.04.004

• Decoding the regulatory network of early blood development from single-cell gene expression measurements

  Nature Biotechnology · 2015 · 10.1038/nbt.3154

• Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions

  Cell stem cell · 2015 · 10.1016/j.stem.2015.05.003

• Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal

  Cell stem cell · 2014 · https://doi.org/10.1016/j.stem.2014.03.002

• The Epidermis Comprises Autonomous Compartments Maintained by Distinct Stem Cell Populations

  Cell stem cell · 2013 · 10.1016/j.stem.2013.07.010

• Large conserved domains of low DNA methylation maintained by Dnmt3a

  Nature Genetics · 2013 · 10.1038/ng.2836

• Esrrb Is a Pivotal Target of the Gsk3/Tcf3 Axis Regulating Embryonic Stem Cell Self-Renewal

  Cell stem cell · 2012 · 10.1016/j.stem.2012.06.008

• Combinatorial Transcriptional Control In Blood Stem/Progenitor Cells: Genome-wide Analysis of Ten Major Transcriptional Regulators

  Cell stem cell · 2010 · 10.1016/j.stem.2010.07.016

• JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin

  Nature · 2009 · 10.1038/nature08448

• Proneural bHLH and Brn Proteins Coregulate a Neurogenic Program through Cooperative Binding to a Conserved DNA Motif

  Developmental Cell · 2006 · 10.1016/j.devcel.2006.10.006

• Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes

  Proceedings of the National Academy of Sciences · 2004 · 10.1073/pnas.0401827101

• The SCL gene specifies haemangioblast development from early mesoderm

  The EMBO Journal · 1998 · 10.1093/emboj/17.14.4029

Current projects

No projects listed.