Robin J.M. Franklin

Research interests

Publications

• Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain

  Nature Neuroscience · 2022 · 10.1038/s41593-022-01022-8

• Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer’s disease risk genes

  Nature Genetics · 2021 · 10.1038/s41588-020-00776-w

• Niche stiffness underlies the ageing of central nervous system progenitor cells

  Nature · 2019 · https://doi.org/10.1038/s41586-019-1484-9

• Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells

  Cell stem cell · 2019 · 10.1016/j.stem.2019.08.015

• Neuronal vulnerability and multilineage diversity in multiple sclerosis

  Nature · 2019 · https://doi.org/10.1038/s41586-019-1404-z

• Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

  Immunity · 2018 · https://doi.org/10.1016/j.immuni.2018.11.004

• Regenerating CNS myelin — from mechanisms to experimental medicines

  Nature reviews. Neuroscience · 2017 · 10.1038/nrn.2017.136

• Regulatory T cells promote myelin regeneration in the central nervous system

  Nature Neuroscience · 2017 · 10.1038/nn.4528

• Multiple sclerosis genetics

  The Lancet Neurology · 2014 · 10.1016/s1474-4422(14)70041-9

• Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis

  Nature Medicine · 2014 · 10.1038/nm.3618

• M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

  Nature Neuroscience · 2013 · https://doi.org/10.1038/nn.3469

• Rejuvenation of Regeneration in the Aging Central Nervous System

  Cell stem cell · 2012 · 10.1016/j.stem.2011.11.019

• Retinoid X receptor gamma signaling accelerates CNS remyelination

  Nature Neuroscience · 2010 · 10.1038/nn.2702

• CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination

  Cell stem cell · 2010 · https://doi.org/10.1016/j.stem.2010.04.002

• Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS

  Genes & Development · 2009 · 10.1101/gad.1806309

• Remyelination in the CNS: from biology to therapy

  Nature reviews. Neuroscience · 2008 · 10.1038/nrn2480

• Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency

  Nature Neuroscience · 2008 · 10.1038/nn.2172

• Debris clearance by microglia: an essential link between degeneration and regeneration

  Brain · 2008 · 10.1093/brain/awn109

• Neuregulin-1/ErbB Signaling Serves Distinct Functions in Myelination of the Peripheral and Central Nervous System

  Neuron · 2008 · 10.1016/j.neuron.2008.06.028

• Myelin Impairs CNS Remyelination by Inhibiting Oligodendrocyte Precursor Cell Differentiation

  Journal of Neuroscience · 2006 · 10.1523/jneurosci.2615-05.2006

• bHLH Transcription Factor Olig1 Is Required to Repair Demyelinated Lesions in the CNS

  Science · 2004 · 10.1126/science.1103709

• The Age-Related Decrease in CNS Remyelination Efficiency Is Attributable to an Impairment of Both Oligodendrocyte Progenitor Recruitment and Differentiation

  Journal of Neuroscience · 2002 · 10.1523/jneurosci.22-07-02451.2002

• Why does remyelination fail in multiple sclerosis?

  Nature reviews. Neuroscience · 2002 · 10.1038/nrn917

• Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin‐induced demyelination

  Glia · 2001 · 10.1002/glia.1085

• Repair of demyelinated lesions by transplantation of purified 0-2A progenitor cells

  Nature · 1993 · 10.1038/362453a0

Current projects

No projects listed.