John V. Pearson

Research interests

Publications

• Deep learning in cancer diagnosis, prognosis and treatment selection

  Genome Medicine · 2021 · https://doi.org/10.1186/s13073-021-00968-x

• Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-019-0564-y

• Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-019-0576-7

• Patterns of somatic structural variation in human cancer genomes

  Nature · 2020 · https://doi.org/10.1038/s41586-019-1913-9

• Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-019-0562-0

• Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets

  Nature Communications · 2019 · 10.1038/s41467-019-11107-x

• CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

  Nature Communications · 2019 · 10.1038/s41467-019-10968-6

• Whole-genome landscapes of major melanoma subtypes

  Nature · 2017 · https://doi.org/10.1038/nature22071

• Genomic analyses identify molecular subtypes of pancreatic cancer

  Nature · 2016 · https://doi.org/10.1038/nature16965

• Whole–genome characterization of chemoresistant ovarian cancer

  Nature · 2015 · https://doi.org/10.1038/nature14410

• A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing

  Nature Communications · 2015 · 10.1038/ncomms10001

• Whole genomes redefine the mutational landscape of pancreatic cancer

  Nature · 2015 · https://doi.org/10.1038/nature14169

• Pathway and network analysis of cancer genomes

  Nature Methods · 2015 · https://doi.org/10.1038/nmeth.3440

• Genome‐wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT‐ROBO, ITGA2 and MET signaling

  International Journal of Cancer · 2014 · 10.1002/ijc.28765

• Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis

  Nature Communications · 2014 · 10.1038/ncomms6224

• Signatures of mutational processes in human cancer

  Nature · 2013 · https://doi.org/10.1038/nature12477

• PINA v2.0: mining interactome modules

  Nucleic Acids Research · 2011 · https://doi.org/10.1093/nar/gkr967

• Genetic Control of Human Brain Transcript Expression in Alzheimer Disease

  The American Journal of Human Genetics · 2009 · 10.1016/j.ajhg.2009.03.011

• Resolving Individuals Contributing Trace Amounts of DNA to Highly Complex Mixtures Using High-Density SNP Genotyping Microarrays

  PLoS Genetics · 2008 · https://doi.org/10.1371/journal.pgen.1000167

• Identification of genetic variants using bar-coded multiplexed sequencing

  Nature Methods · 2008 · 10.1038/nmeth.1251

• Whole-Genome Analysis of Sporadic Amyotrophic Lateral Sclerosis

  New England Journal of Medicine · 2007 · 10.1056/nejmoa070174

• A High-Density Whole-Genome Association Study Reveals That APOE Is the Major Susceptibility Gene for Sporadic Late-Onset Alzheimer's Disease

  The Journal of Clinical Psychiatry · 2007 · https://doi.org/10.4088/jcp.v68n0419

• A survey of genetic human cortical gene expression

  Nature Genetics · 2007 · https://doi.org/10.1038/ng.2007.16

• GAB2 Alleles Modify Alzheimer's Risk in APOE ɛ4 Carriers

  Neuron · 2007 · https://doi.org/10.1016/j.neuron.2007.05.022

• Common Kibra Alleles Are Associated with Human Memory Performance

  Science · 2006 · https://doi.org/10.1126/science.1129837

Current projects

No projects listed.