Shinya Yamanaka

Research interests

Publications

• Pluripotent Stem Cell-Based Cell Therapy—Promise and Challenges

  Cell stem cell · 2020 · 10.1016/j.stem.2020.09.014

• Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development

  Physiological Reviews · 2018 · https://doi.org/10.1152/physrev.00039.2017

• Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration

  New England Journal of Medicine · 2017 · 10.1056/nejmoa1608368

• Induced pluripotent stem cell technology: a decade of progress

  Nature Reviews Drug Discovery · 2016 · https://doi.org/10.1038/nrd.2016.245

• A decade of transcription factor-mediated reprogramming to pluripotency

  Nature Reviews Molecular Cell Biology · 2016 · 10.1038/nrm.2016.8

• Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells

  Cell stem cell · 2015 · https://doi.org/10.1016/j.stem.2015.06.014

• Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells

  Nature Communications · 2013 · https://doi.org/10.1038/ncomms2378

• Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

  Cell stem cell · 2013 · https://doi.org/10.1016/j.stem.2013.01.009

• Ultrastructural Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes in a Long-Term Culture

  Circulation Journal · 2013 · https://doi.org/10.1253/circj.cj-12-0987

• Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells

  Science Translational Medicine · 2012 · https://doi.org/10.1126/scitranslmed.3004052

• Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells

  Proceedings of the National Academy of Sciences · 2012 · https://doi.org/10.1073/pnas.1209979109

• Grafted human-induced pluripotent stem-cell–derived neurospheres promote motor functional recovery after spinal cord injury in mice

  Proceedings of the National Academy of Sciences · 2011 · https://doi.org/10.1073/pnas.1108077108

• A more efficient method to generate integration-free human iPS cells

  Nature Methods · 2011 · 10.1038/nmeth.1591

• Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells

  The Journal of Experimental Medicine · 2010 · https://doi.org/10.1084/jem.20100844

• Variation in the safety of induced pluripotent stem cell lines

  Nature Biotechnology · 2009 · https://doi.org/10.1038/nbt.1554

• Hypoxia Enhances the Generation of Induced Pluripotent Stem Cells

  Cell stem cell · 2009 · https://doi.org/10.1016/j.stem.2009.08.001

• Suppression of induced pluripotent stem cell generation by the p53–p21 pathway

  Nature · 2009 · https://doi.org/10.1038/nature08235

• Nanog Is the Gateway to the Pluripotent Ground State

  Cell · 2009 · 10.1016/j.cell.2009.07.039

• Generation of retinal cells from mouse and human induced pluripotent stem cells

  Neuroscience Letters · 2009 · https://doi.org/10.1016/j.neulet.2009.04.035

• Induction of Pluripotent Stem Cells From Adult Human Fibroblasts by Defined Factors

  Obstetrical & Gynecological Survey · 2008 · 10.1097/01.ogx.0000305204.97355.0d

• Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors

  Science · 2008 · 10.1126/science.1164270

• Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells

  Science · 2008 · 10.1126/science.1154884

• Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

  Cell · 2007 · https://doi.org/10.1016/j.cell.2007.11.019

• Induction of pluripotent stem cells from fibroblast cultures

  Nature Protocols · 2007 · 10.1038/nprot.2007.418

• Generation of germline-competent induced pluripotent stem cells

  Nature · 2007 · https://doi.org/10.1038/nature05934

• Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts

  Nature Biotechnology · 2007 · https://doi.org/10.1038/nbt1374

• Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors

  Cell · 2006 · https://doi.org/10.1016/j.cell.2006.07.024

• Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin

  Science · 2004 · 10.1126/science.1097243

• The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells

  Cell · 2003 · https://doi.org/10.1016/s0092-8674(03)00393-3

• Role of ERas in promoting tumour-like properties in mouse embryonic stem cells

  Nature · 2003 · https://doi.org/10.1038/nature01646

Current projects

No projects listed.