Seishi Ogawa

Research interests

Publications

• Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia

  Blood · 2022 · https://doi.org/10.1182/blood.2022015853

• Germ line DDX41 mutations define a unique subtype of myeloid neoplasms

  Blood · 2022 · https://doi.org/10.1182/blood.2022018221

• Molecular International Prognostic Scoring System for Myelodysplastic Syndromes

  NEJM Evidence · 2022 · https://doi.org/10.1056/evidoa2200008

• International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data

  Blood · 2022 · https://doi.org/10.1182/blood.2022015850

• Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes

  Nature Medicine · 2020 · https://doi.org/10.1038/s41591-020-1008-z

• SF3B1-mutant MDS as a distinct disease subtype: a proposal from the International Working Group for the Prognosis of MDS

  Blood · 2020 · https://doi.org/10.1182/blood.2020004850

• TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups

  Leukemia · 2019 · https://doi.org/10.1038/s41375-018-0351-2

• Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis

  Nature · 2019 · https://doi.org/10.1038/s41586-019-1856-1

• Age-related remodelling of oesophageal epithelia by mutated cancer drivers

  Nature · 2018 · 10.1038/s41586-018-0811-x

• Genetic abnormalities in myelodysplasia and secondary acute myeloid leukemia: impact on outcome of stem cell transplantation

  Blood · 2017 · https://doi.org/10.1182/blood-2016-12-754796

• Prognostic relevance of genetic alterations in diffuse lower-grade gliomas

  Neuro-Oncology · 2017 · https://doi.org/10.1093/neuonc/nox132

• Clinical significance of somatic mutation in unexplained blood cytopenia

  Blood · 2017 · 10.1182/blood-2017-01-763425

• Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population

  Gastroenterology · 2016 · https://doi.org/10.1053/j.gastro.2016.01.035

• Dynamics of clonal evolution in myelodysplastic syndromes

  Nature Genetics · 2016 · https://doi.org/10.1038/ng.3742

• Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers

  Nature · 2016 · 10.1038/nature18294

• Mutational landscape and clonal architecture in grade II and III gliomas

  Nature Genetics · 2015 · https://doi.org/10.1038/ng.3273

• Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia

  New England Journal of Medicine · 2015 · https://doi.org/10.1056/nejmoa1414799

• Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms

  Cancer Cell · 2015 · https://doi.org/10.1016/j.ccell.2015.03.017

• Integrated molecular analysis of adult T cell leukemia/lymphoma

  Nature Genetics · 2015 · https://doi.org/10.1038/ng.3415

• Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria

  Journal of Clinical Investigation · 2014 · https://doi.org/10.1172/jci74747

• Genomic and molecular characterization of esophageal squamous cell carcinoma

  Nature Genetics · 2014 · 10.1038/ng.2935

• Somatic RHOA mutation in angioimmunoblastic T cell lymphoma

  Nature Genetics · 2014 · 10.1038/ng.2872

• Integrated molecular analysis of clear-cell renal cell carcinoma

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2699

• Landscape of genetic lesions in 944 patients with myelodysplastic syndromes

  Leukemia · 2013 · https://doi.org/10.1038/leu.2013.336

• Somatic SETBP1 mutations in myeloid malignancies

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2696

• Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2698

• Landscape Of Genetic Lesions In 944 Patients With Myelodysplastic Syndromes

  Blood · 2013 · 10.1182/blood.v122.21.521.521

• Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms

  Nature Genetics · 2013 · 10.1038/ng.2731

• KIF5B-RET fusions in lung adenocarcinoma

  Nature Medicine · 2012 · 10.1038/nm.2644

• Frequent pathway mutations of splicing machinery in myelodysplasia

  Nature · 2011 · https://doi.org/10.1038/nature10496

• Frequent inactivation of A20 in B-cell lymphomas

  Nature · 2009 · 10.1038/nature07969

• Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms

  Nature · 2009 · 10.1038/nature08240

• Oncogenic mutations of ALK kinase in neuroblastoma

  Nature · 2008 · https://doi.org/10.1038/nature07399

• A Robust Algorithm for Copy Number Detection Using High-Density Oligonucleotide Single Nucleotide Polymorphism Genotyping Arrays

  Cancer Research · 2005 · 10.1158/0008-5472.can-05-0465

• Notch1 but Not Notch2 Is Essential for Generating Hematopoietic Stem Cells from Endothelial Cells

  Immunity · 2003 · 10.1016/s1074-7613(03)00117-1

• A novel signaling molecule, p130, forms stable complexes in vivo with v‐Crk and v‐Src in a tyrosine phosphorylation‐dependent manner.

  The EMBO Journal · 1994 · 10.1002/j.1460-2075.1994.tb06684.x

Current projects

No projects listed.