Frank Claessens

Research interests

Publications

• An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-020-17673-9

• Shared heritability and functional enrichment across six solid cancers

  Nature Communications · 2019 · https://doi.org/10.1038/s41467-018-08054-4

• Large-scale transcriptome-wide association study identifies new prostate cancer risk regions

  Nature Communications · 2018 · https://doi.org/10.1038/s41467-018-06302-1

• Structure of the homodimeric androgen receptor ligand-binding domain

  Nature Communications · 2017 · https://doi.org/10.1038/ncomms14388

• Sex hormone-binding globulin regulation of androgen bioactivity in vivo: validation of the free hormone hypothesis

  Scientific Reports · 2016 · https://doi.org/10.1038/srep35539

• Low Free Testosterone Is Associated with Hypogonadal Signs and Symptoms in Men with Normal Total Testosterone

  The Journal of Clinical Endocrinology & Metabolism · 2016 · https://doi.org/10.1210/jc.2015-4106

• Estrogens and Androgens in Skeletal Physiology and Pathophysiology

  Physiological Reviews · 2016 · https://doi.org/10.1152/physrev.00033.2015

• Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331 288 participants

  The Lancet Diabetes & Endocrinology · 2015 · https://doi.org/10.1016/s2213-8587(15)00129-1

• Sex Steroid Actions in Male Bone

  Endocrine Reviews · 2014 · https://doi.org/10.1210/er.2014-1024

• Sarcopenia and its relationship with bone mineral density in middle-aged and elderly European men

  Osteoporosis International · 2012 · https://doi.org/10.1007/s00198-012-2057-z

• Fracture Risk and Zoledronic Acid Therapy in Men with Osteoporosis

  New England Journal of Medicine · 2012 · https://doi.org/10.1056/nejmoa1204061

• Androgens and skeletal muscle: cellular and molecular action mechanisms underlying the anabolic actions

  Cellular and Molecular Life Sciences · 2011 · https://doi.org/10.1007/s00018-011-0883-3

• Diverse roles of androgen receptor (AR) domains in AR-mediated signaling

  Nuclear Receptor Signaling · 2008 · https://doi.org/10.1621/nrs.06008

• Structural basis of androgen receptor binding to selective androgen response elements

  Proceedings of the National Academy of Sciences · 2004 · https://doi.org/10.1073/pnas.0401123101

• A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis

  Proceedings of the National Academy of Sciences · 2004 · https://doi.org/10.1073/pnas.0308114100

• Selective DNA binding by the androgen receptor as a mechanism for hormone-specific gene regulation

  The Journal of Steroid Biochemistry and Molecular Biology · 2001 · https://doi.org/10.1016/s0960-0760(00)00154-0

• The Androgen Receptor Amino-Terminal Domain Plays a Key Role in p160 Coactivator-Stimulated Gene Transcription

  Molecular and Cellular Biology · 1999 · https://doi.org/10.1128/mcb.19.9.6085

• The AF1 and AF2 Domains of the Androgen Receptor Interact with Distinct Regions of SRC1

  Molecular and Cellular Biology · 1999 · https://doi.org/10.1128/mcb.19.12.8383

Current projects

No projects listed.