Heather P. Harding

Research interests

Publications

• GDF15 mediates the effects of metformin on body weight and energy balance

  Nature · 2019 · 10.1038/s41586-019-1911-y

• Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2

  New England Journal of Medicine · 2013 · https://doi.org/10.1056/nejmoa1312542

• Targeting the unfolded protein response in disease

  Nature Reviews Drug Discovery · 2013 · 10.1038/nrd3976

• The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

  Proceedings of the National Academy of Sciences · 2012 · 10.1073/pnas.1115623109

• Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis

  The Journal of Cell Biology · 2009 · 10.1083/jcb.200904060

• GCN2 Kinase in T Cells Mediates Proliferative Arrest and Anergy Induction in Response to Indoleamine 2,3-Dioxygenase

  Immunity · 2005 · 10.1016/j.immuni.2005.03.013

• A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress

  Science · 2005 · https://doi.org/10.1126/science.1101902

• ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

  The EMBO Journal · 2005 · 10.1038/sj.emboj.7600777

• Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

  The Journal of Cell Biology · 2004 · 10.1083/jcb.200408003

• CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

  Genes & Development · 2004 · https://doi.org/10.1101/gad.1250704

• Translational Repression Mediates Activation of Nuclear Factor Kappa B by Phosphorylated Translation Initiation Factor 2

  Molecular and Cellular Biology · 2004 · 10.1128/mcb.24.23.10161-10168.2004

• Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones

  Journal of Cell Science · 2004 · 10.1242/jcs.01275

• The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

  Nature Cell Biology · 2003 · 10.1038/ncb1035

• An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

  Molecular Cell · 2003 · https://doi.org/10.1016/s1097-2765(03)00105-9

• Endoplasmic Reticulum Stress and the Unfolded Protein Response in Cellular Models of Parkinson's Disease

  Journal of Neuroscience · 2002 · 10.1523/jneurosci.22-24-10690.2002

• IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

  Nature · 2002 · https://doi.org/10.1038/415092a

• Transcriptional and Translational Control in the Mammalian Unfolded Protein Response

  Annual Review of Cell and Developmental Biology · 2002 · 10.1146/annurev.cellbio.18.011402.160624

• Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α

  The Journal of Cell Biology · 2001 · 10.1083/jcb.153.5.1011

• Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival

  Molecular Cell · 2001 · 10.1016/s1097-2765(01)00264-7

• Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

  Nature Cell Biology · 2000 · 10.1038/35014014

• Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response

  Molecular Cell · 2000 · 10.1016/s1097-2765(00)80330-5

• Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

  Science · 2000 · 10.1126/science.287.5453.664

• Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

  Molecular Cell · 2000 · 10.1016/s1097-2765(00)00108-8

• Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

  Nature · 1999 · 10.1038/16729

• Differential Activation of Peroxisome Proliferator-activated Receptors by Eicosanoids

  Journal of Biological Chemistry · 1995 · 10.1074/jbc.270.41.23975

Current projects

No projects listed.