Stefan J. Marciniak

Research interests

Publications

• Pharmacological targeting of endoplasmic reticulum stress in disease

  Nature Reviews Drug Discovery · 2021 · https://doi.org/10.1038/s41573-021-00320-3

• COVID-19 and pneumothorax: a multicentre retrospective case series

  European Respiratory Journal · 2020 · https://doi.org/10.1183/13993003.02697-2020

• An Optical Technique for Mapping Microviscosity Dynamics in Cellular Organelles

  ACS Nano · 2018 · https://doi.org/10.1021/acsnano.8b00177

• α1-Antitrypsin deficiency

  Nature Reviews Disease Primers · 2016 · https://doi.org/10.1038/nrdp.2016.51

• Endoplasmic Reticulum Stress in Malignancy

  Cancer Cell · 2014 · https://doi.org/10.1016/j.ccr.2014.03.015

• The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress

  Nature · 2014 · https://doi.org/10.1038/nature13228

• Chloroquine Prevents Progression of Experimental Pulmonary Hypertension via Inhibition of Autophagy and Lysosomal Bone Morphogenetic Protein Type II Receptor Degradation

  Circulation Research · 2013 · https://doi.org/10.1161/circresaha.111.300483

• Paneth cells as a site of origin for intestinal inflammation

  Nature · 2013 · https://doi.org/10.1038/nature12599

• Endoplasmic reticulum dysfunction in neurological disease

  The Lancet Neurology · 2012 · https://doi.org/10.1016/s1474-4422(12)70238-7

• Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells

  Nature · 2011 · https://doi.org/10.1038/nature10424

• A Novel Monoclonal Antibody to Characterize Pathogenic Polymers in Liver Disease Associated with α1-Antitrypsin Deficiency†

  Hepatology · 2010 · https://doi.org/10.1002/hep.23760

• Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells

  Journal of Clinical Investigation · 2010 · https://doi.org/10.1172/jci43122

• Iron Promotes the Toxicity of Amyloid β Peptide by Impeding Its Ordered Aggregation

  Journal of Biological Chemistry · 2010 · https://doi.org/10.1074/jbc.m110.158980

• Endoplasmic Reticulum Stress Signaling in Disease

  Physiological Reviews · 2006 · https://doi.org/10.1152/physrev.00015.2006

• Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK

  The Journal of Cell Biology · 2006 · https://doi.org/10.1083/jcb.200508099

• Cytoprotection by pre‐emptive conditional phosphorylation of translation initiation factor 2

  The EMBO Journal · 2004 · https://doi.org/10.1038/sj.emboj.7600030

• CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

  Genes & Development · 2004 · https://doi.org/10.1101/gad.1250704

Current projects

No projects listed.