Gillian M. Griffiths

Research interests

Publications

• An early history of T cell-mediated cytotoxicity

  Nature reviews. Immunology · 2018 · 10.1038/s41577-018-0009-3

• Mutations in AP3D1 associated with immunodeficiency and seizures define a new type of Hermansky-Pudlak syndrome

  Blood · 2016 · 10.1182/blood-2015-09-671636

• Actin Depletion Initiates Events Leading to Granule Secretion at the Immunological Synapse

  Immunity · 2015 · 10.1016/j.immuni.2015.04.013

• Genetic predisposition to hemophagocytic lymphohistiocytosis: Report on 500 patients from the Italian registry

  Journal of Allergy and Clinical Immunology · 2015 · 10.1016/j.jaci.2015.06.048

• The Biogenesis of Lysosomes and Lysosome-Related Organelles

  Cold Spring Harbor Perspectives in Biology · 2014 · 10.1101/cshperspect.a016840

• The immunological synapse: a focal point for endocytosis and exocytosis

  The Journal of Cell Biology · 2010 · 10.1083/jcb.201002027

• Familial Hemophagocytic Lymphohistiocytosis Type 5 (FHL-5) Is Caused by Mutations in Munc18-2 and Impaired Binding to Syntaxin 11

  The American Journal of Human Genetics · 2009 · 10.1016/j.ajhg.2009.09.005

• Secretory Mechanisms in Cell-Mediated Cytotoxicity

  Annual Review of Cell and Developmental Biology · 2007 · 10.1146/annurev.cellbio.23.090506.123521

• The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation

  The Journal of Experimental Medicine · 2007 · 10.1084/jem.20062342

• Analysis of natural killer–cell function in familial hemophagocytic lymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13-4 defect and discriminates between genetic subtypes of the disease

  Blood · 2006 · 10.1182/blood-2006-04-015693

• Centrosome polarization delivers secretory granules to the immunological synapse

  Nature · 2006 · https://doi.org/10.1038/nature05071

• Structural and kinetic basis for heightened immunogenicity of T cell vaccines

  The Journal of Experimental Medicine · 2005 · 10.1084/jem.20042323

• Linking Albinism and Immunity: The Secrets of Secretory Lysosomes

  Science · 2004 · 10.1126/science.1095291

• Spread of HTLV-I Between Lymphocytes by Virus-Induced Polarization of the Cytoskeleton

  Science · 2003 · https://doi.org/10.1126/science.1080115

• Adaptor protein 3–dependent microtubule-mediated movement of lytic granules to the immunological synapse

  Nature Immunology · 2003 · 10.1038/ni1000

• Delivering the kiss of death

  Nature Immunology · 2003 · 10.1038/ni0503-399

• Secretory lysosomes

  Nature Reviews Molecular Cell Biology · 2002 · https://doi.org/10.1038/nrm732

• The Immunological Synapse of CTL Contains a Secretory Domain and Membrane Bridges

  Immunity · 2001 · https://doi.org/10.1016/s1074-7613(01)00234-5

• Rab27a Is Required for Regulated Secretion in Cytotoxic T Lymphocytes

  The Journal of Cell Biology · 2001 · 10.1083/jcb.152.4.825

• Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells

  Nature Medicine · 1999 · 10.1038/4779

• Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid‐binding C2 domain

  The EMBO Journal · 1997 · 10.1093/emboj/16.24.7287

• Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re‐filling of the lytic granules and secretion of lytic proteins via a non‐granule pathway

  European Journal of Immunology · 1995 · 10.1002/eji.1830250432

• Molecular events during maturation of the immune response to oxazolone

  Nature · 1985 · 10.1038/316412a0

• Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

  Nature · 1984 · https://doi.org/10.1038/312271a0

• mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification

  Nature · 1983 · 10.1038/304320a0

Current projects

No projects listed.