Paul Lyons

Research interests

Publications

• A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial

  ˜The œLancet. Gastroenterology & hepatology · 2024 · https://doi.org/10.1016/s2468-1253(24)00034-7

• A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial

  ˜The œLancet. Gastroenterology & hepatology · 2024 · https://doi.org/10.1016/s2468-1253(24)00034-7

• Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity

  Nature · 2022 · https://doi.org/10.1038/s41586-022-04474-x

• SARS-CoV-2 evolution during treatment of chronic infection

  Nature · 2021 · https://doi.org/10.1038/s41586-021-03291-y

• Single-cell multi-omics analysis of the immune response in COVID-19

  Nature Medicine · 2021 · https://doi.org/10.1038/s41591-021-01329-2

• Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

  Nature · 2021 · https://doi.org/10.1038/s41586-021-03412-7

• Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease

  Immunity · 2021 · https://doi.org/10.1016/j.immuni.2021.05.010

• ANCA-associated vasculitis

  Nature Reviews Disease Primers · 2020 · https://doi.org/10.1038/s41572-020-0204-y

• A thermostable, closed SARS-CoV-2 spike protein trimer

  Nature Structural & Molecular Biology · 2020 · https://doi.org/10.1038/s41594-020-0478-5

• Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission

  eLife · 2020 · https://doi.org/10.7554/elife.58728

• Analysis of the B cell receptor repertoire in six immune-mediated diseases

  Nature · 2019 · https://doi.org/10.1038/s41586-019-1595-3

• Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status

  Nature Communications · 2019 · https://doi.org/10.1038/s41467-019-12515-9

• Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease

  Nature Genetics · 2017 · https://doi.org/10.1038/ng.3755

• T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection

  Nature · 2015 · https://doi.org/10.1038/nature14468

• A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes

  Diabetes · 2014 · https://doi.org/10.2337/db13-1777

• Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway

  Cell · 2013 · https://doi.org/10.1016/j.cell.2013.08.034

• Genetically Distinct Subsets within ANCA-Associated Vasculitis

  New England Journal of Medicine · 2012 · https://doi.org/10.1056/nejmoa1108735

• Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis

  Journal of Clinical Investigation · 2011 · https://doi.org/10.1172/jci59255

• A CD8+ T cell transcription signature predicts prognosis in autoimmune disease

  Nature Medicine · 2010 · https://doi.org/10.1038/nm.2130

• Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake

  The Journal of Experimental Medicine · 2008 · https://doi.org/10.1084/jem.20072413

• Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

  Nature Genetics · 2007 · https://doi.org/10.1038/ng1958

• Functional annotation of a full-length mouse cDNA collection

  Nature · 2001 · https://doi.org/10.1038/35055500

Current projects

No projects listed.